Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 rue University, Montreal, QC, H3A 2B4, Canada.
Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge CB2 7EF, UK; Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK.
Trends Cogn Sci. 2018 May;22(5):422-437. doi: 10.1016/j.tics.2018.02.011. Epub 2018 Mar 22.
Attention alters three key properties of population neural activity - firing rate, rate variability, and shared variability between neurons. All three properties are well explained by a single canonical computation - normalization - that acts across hierarchically integrated brain systems. Combining data from rodents and nonhuman primates, we argue that cortical cholinergic modulation originating from the basal forebrain closely mimics the effects of directed attention on these three properties of population neural activity. Cholinergic modulation of the cortical microcircuit underlying normalization may represent a key biological basis for the rapid and flexible changes in population neuronal coding that are required by directed attention.
注意改变了群体神经活动的三个关键特性——发放率、发放率变异性和神经元之间的共享变异性。这三个特性都可以通过一个单一的规范计算来很好地解释，即归一化，它作用于层次化整合的大脑系统。我们结合了啮齿动物和非人类灵长类动物的数据，认为起源于基底前脑的皮质胆碱能调制紧密模拟了定向注意对群体神经活动这三个特性的影响。归一化的皮质微电路的胆碱能调制可能代表了定向注意所需要的群体神经元编码快速灵活变化的关键生物学基础。
