氯贝丁酯改善了部分而非所有犬种的脂质代谢。
Clinofibrate improved canine lipid metabolism in some but not all breeds.
作者信息
Sato Yohtaro, Arai Nobuaki, Yasuda Hidemi, Mizoguchi Yasushi
机构信息
Graduate School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan.
Spectrum Lab Japan, 1-5-22-201 Midorigaoka, Meguro-ku, Tokyo 152-0034, Japan.
出版信息
J Vet Med Sci. 2018 Jun 29;80(6):945-949. doi: 10.1292/jvms.17-0703. Epub 2018 Mar 26.
The objectives of this study were to assess if Clinofibrate (CF) treatment improved lipid metabolism in dogs, and to clarify whether its efficacy is influenced by canine characteristics. We collected medical records of 306 dogs and performed epidemiological analyses. Lipid values of all lipoproteins were significantly decreased by CF medication, especially VLDL triglyceride (TG) concentration (mean reduction rate=54.82%). However, 17.65% of dogs showed drug refractoriness in relation to TG level, and Toy Poodles had a lower CF response than other breeds (OR=5.36, 95% CI=2.07-13.90). Therefore, our study suggests that genetic factors may have an effect on CF response, so genetic studies on lipid metabolism-related genes might be conducted to identify variations in CF efficacy.
本研究的目的是评估克利贝特（CF）治疗是否能改善犬类的脂质代谢，并阐明其疗效是否受犬类特征的影响。我们收集了306只犬的病历并进行了流行病学分析。CF药物治疗使所有脂蛋白的脂质值均显著降低，尤其是极低密度脂蛋白甘油三酯（TG）浓度（平均降低率=54.82%）。然而，17.65%的犬在TG水平方面表现出药物难治性，且玩具贵宾犬对CF的反应低于其他品种（OR=5.36，95%CI=2.07-13.90）。因此，我们的研究表明遗传因素可能对CF反应有影响，所以可能需要对脂质代谢相关基因进行遗传学研究，以确定CF疗效的差异。
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