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飞秒激光原位角膜磨镶术(FS-LASIK)后残余角膜床厚度小于原角膜厚度50%时的角膜生物力学特性

Corneal Biomechanical Properties after FS-LASIK with Residual Bed Thickness Less Than 50% of the Original Corneal Thickness.

作者信息

Zhang Haixia, Khan Muhammad Ahmad, Zhang Di, Qin Xiao, Lin Ding, Li Lin

机构信息

School of Biomedical Engineering, Capital Medical University, Beijing 100069, China.

Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China.

出版信息

J Ophthalmol. 2018 Jan 11;2018:2752945. doi: 10.1155/2018/2752945. eCollection 2018.

Abstract

BACKGROUND

The changes in corneal biomechanical properties after LASIK remain an unknown but important topic for surgical design and prognostic evaluation. This study aims to observe the postoperative corneal biomechanical properties one month after LASIK with amount of corneal cutting (ACC) greater than 50% of the central corneal thickness (CCT).

METHODS

FS-LASIK was performed in 10 left rabbit eyes with ACC being 60% (L60) and 65% (L65) of the CCT, while the right eyes (R) were the control. After 4 weeks, rabbits were executed and corneal strip samples were prepared for uniaxial tensile tests.

RESULTS

At the same strain, the stresses of L65 and L60 were larger than those of R. The elastic moduli of L60 and L65 were larger than those of R when the stress was 0.02 MPa, while they began to be less than those of R when stress exceeds the low-stress region. After 10 s relaxation, the stress of specimens L65, L60, and R increased in turn.

CONCLUSION

The elastic moduli of the cornea after FS-LASIK with ACC greater than 50% of the CCT do not become less under normal rabbit IOP. The limit stress grows with the rise of ACC when relaxation becomes stable.

摘要

背景

准分子激光原位角膜磨镶术(LASIK)后角膜生物力学特性的变化仍是一个未知但对手术设计和预后评估很重要的课题。本研究旨在观察角膜切削量(ACC)大于中央角膜厚度(CCT)50%的LASIK术后1个月时角膜的生物力学特性。

方法

对10只兔的左眼行飞秒激光制瓣准分子原位角膜磨镶术(FS-LASIK),ACC分别为CCT的60%(L60组)和65%(L65组),右眼作为对照。4周后处死兔子,制备角膜条样本进行单轴拉伸试验。

结果

在相同应变下,L65组和L60组的应力大于对照组。当应力为0.02 MPa时,L60组和L65组的弹性模量大于对照组,而当应力超过低应力区时,它们开始小于对照组。10 s松弛后,L65组、L60组和对照组样本的应力依次增加。

结论

在正常兔眼压下,ACC大于CCT 50%的FS-LASIK术后角膜弹性模量不会降低。当松弛稳定时,极限应力随ACC的增加而增大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82f4/5821977/93071dcfce97/JOPH2018-2752945.001.jpg

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