一种用于活细胞内内源性 HClO 快速感应的高灵敏和高选择性荧光探针。
A highly sensitive and selective fluorescent probe for fast sensing of endogenous HClO in living cells.
机构信息
State Key Laboratory of Organic-Inorganic Composites and Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China.
出版信息
Chem Commun (Camb). 2018 Apr 12;54(31):3835-3838. doi: 10.1039/c8cc01917g.
A new fluorescence probe was developed for HClO detection under physiological conditions, which displayed fast response (t1/2 < 30 s) and large off-on fluorescence increase (>1000-fold) toward HClO with high sensitivity and selectivity. The probe was successfully applied for the detection of both exogenous and endogenous HClO in living cells. Using the probe-based tool, we could observe the H2S-induced HClO biogenesis in living cells for the first time.
一种新的荧光探针被开发用于在生理条件下检测 HClO，该探针对 HClO 具有快速响应（t1/2 < 30 s）和大的开-关荧光增强（> 1000 倍），具有高灵敏度和选择性。该探针成功应用于活细胞中外源和内源性 HClO 的检测。使用基于探针的工具，我们首次能够观察到活细胞中 H2S 诱导的 HClO 生成。
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