Sinyakova N A, Kulikova E A, Englevskii N A, Kulikov A V
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2018 Mar;164(5):620-623. doi: 10.1007/s10517-018-4045-6. Epub 2018 Mar 26.
We compared the effect of a new potential antidepressant 8-trifluoromethyl 1,2,3,4,5-benzopentathiepine-6-amine hydrochloride (TC-2153) and classical antidepressant fluoxetine in a dose of 0.25 mg/liter on the behavior of Danio rerio in the "novel tank" test and content of biogenic amines and their metabolites in the brain. Fluoxetine alone and TC-2153 alone significantly increased the time spent in the upper part of the tank and insignificantly reduced motor activity. Combined exposure of fishes in the solution containing potential and classical antidepressants potentiated their effects on both parameters. The compounds did not affect brain contents of serotonin, dopamine, and norepinephrine. At the same time, fluoxetine, but not TC-2153, reduced brain content of the main serotonin metabolite 5-hydroxyindole acetic acid.
我们比较了新型潜在抗抑郁药8-三氟甲基-1,2,3,4,5-苯并五硫杂环庚烷-6-胺盐酸盐（TC-2153）和剂量为0.25毫克/升的经典抗抑郁药氟西汀对斑马鱼在“新水箱”试验中的行为以及大脑中生物胺及其代谢物含量的影响。单独使用氟西汀和单独使用TC-2153均显著增加了鱼在水箱上部停留的时间，并轻微降低了运动活性。将鱼暴露于含有潜在抗抑郁药和经典抗抑郁药的溶液中，会增强它们对这两个参数的影响。这些化合物对大脑中血清素、多巴胺和去甲肾上腺素的含量没有影响。同时，氟西汀降低了大脑中主要血清素代谢物5-羟吲哚乙酸的含量，但TC-2153没有。
