Goobar J P, Fang M, Weisman M H, Zvaifler N, Gigli I
Scand J Rheumatol. 1987;16(4):273-9. doi: 10.3109/03009748709102928.
We have conducted a quantitative analysis of Langerhans cells (LC) in skin biopsies of 20 patients with various connective tissue diseases. Clinically normal skin of SLE patients as well as lesional skin of DLE showed consistently normal LC densities as assessed using ATPase staining, anti-DR and anti-OKT6. Examination of LC in clinically involved skin of patients with scleroderma revealed an absolute or relative decrease in ATPase and OKT6 expression, while staining with anti-DR gave inconclusive results. Clinically normal skin of the same individuals showed basically normal LC density. These findings suggest that the perturbation of the LC population is probably an expression of a secondary local phenomenon, and does not reflect a more widespread derangement of the accessory cells in the skin.
我们对20例患有各种结缔组织疾病患者的皮肤活检样本中的朗格汉斯细胞（LC）进行了定量分析。使用ATP酶染色、抗DR和抗OKT6评估发现，系统性红斑狼疮（SLE）患者的临床正常皮肤以及盘状红斑狼疮（DLE）患者的皮损部位LC密度始终正常。对硬皮病患者临床受累皮肤的LC检测发现，ATP酶和OKT6表达出现绝对或相对降低，而抗DR染色结果不明确。同一患者的临床正常皮肤LC密度基本正常。这些发现表明，LC群体的紊乱可能是一种继发性局部现象的表现，并不反映皮肤中辅助细胞更广泛的紊乱。
