Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria.
Department of Anatomy, University of Ibadan, Ibadan, Nigeria.
Brain Res Bull. 2019 Feb;145:75-80. doi: 10.1016/j.brainresbull.2018.03.010. Epub 2018 Mar 22.
Vanadium, atomic number 23, is a transition metal widely distributed in nature. It is a major contaminant of fossil fuels and is widely used in industry as catalysts, in welding, and making steel alloys. Over the years, vanadium compounds have been generating interests due to their use as therapeutic agents in the control of diabetes, tuberculosis, and some neoplasms. However, the toxicity of vanadium compounds is well documented in literature with occupational exposure of workers in vanadium allied industries, environmental pollution from combustion of fossil fuels and industrial exhausts receiving concerns as major sources of toxicity and a likely predisposing factor in the aetiopathogenesis of neurodegenerative diseases. A lot has been done to understand the neurotoxic effects of vanadium, its mechanisms of action and possible antidotes. Sequel to our review of the subject in 2011, this present review is to detail the recent insights gained in vanadium neurotoxicity.
钒，原子序数 23，是一种广泛存在于自然界中的过渡金属。它是化石燃料的主要污染物，广泛用作工业催化剂、焊接和制造钢合金。多年来，由于钒化合物可用作控制糖尿病、结核病和某些肿瘤的治疗剂，因此引起了人们的兴趣。然而，文献中已有充分证据表明钒化合物具有毒性，从事与钒相关行业的工人职业暴露、燃烧化石燃料造成的环境污染以及工业废气排放，都受到了人们的关注，这些被认为是毒性的主要来源，也是神经退行性疾病发病机制中的一个潜在诱发因素。人们已经做了很多工作来了解钒的神经毒性、作用机制和可能的解毒剂。继我们在 2011 年对该主题进行审查之后，本次审查旨在详细介绍在钒神经毒性方面的最新研究进展。
