N.P. Bechtereva Institute of the Human Brain, Russian Academy of Sciences, 197376, akad. Pavlova str., 9, Saint Petersburg, Russia.
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223, pr. Torez, 44, Saint Petersburg, Russia.
Int J Psychophysiol. 2018 Jun;128:22-30. doi: 10.1016/j.ijpsycho.2018.03.013. Epub 2018 Mar 22.
This study aimed to reveal electrophysiological markers of communicative and cognitive dysfunctions of different severity in children with autism spectrum disorder (ASD). Eyes-opened electroencephalograms (EEGs) of 42 children with ASD, divided into two groups according to the severity of their communicative and cognitive dysfunctions (24 with severe and 18 children with less severe ASD), and 70 age-matched controls aged 4-9 years were examined by means of spectral and group independent component (gIC) analyses. A predominance of theta and beta EEG activity in both groups of children with ASD compared to the activity in the control group was found in the global gIC together with a predominance of beta EEG activity in the right occipital region. The quantity of local gICs with enhanced slow and high-frequency EEG activity (within the frontal, temporal, and parietal cortex areas) in children 4-9 years of age might be considered a marker of cognitive and communicative dysfunction severity.
本研究旨在揭示自闭症谱系障碍（ASD）儿童不同严重程度的交际和认知功能障碍的电生理标志物。通过频谱和组独立成分（gIC）分析，对根据交际和认知功能障碍严重程度分为两组（24 名严重障碍和 18 名轻度障碍 ASD 儿童）的 42 名 ASD 儿童和 70 名年龄匹配的 4-9 岁对照组的睁眼脑电图（EEG）进行了检查。与对照组相比，两组 ASD 儿童的全局 gIC 中均存在θ和β脑电活动占主导地位，右侧枕叶区域存在β脑电活动占主导地位。在 4-9 岁儿童中，局部 gIC 中增强的慢波和高频脑电活动（额、颞和顶叶皮层区域）的数量可能被认为是认知和交际功能障碍严重程度的标志物。
