College of Biotechnology and Bioresources, Da-Yeh University, 168 University Rd., Dacun, Chang-Hua, Taiwan, Republic of China.
Department of Medicinal Botanicals and Health Applications, Da-Yeh University, 168 University Rd, Dacun, Chang-Hua, Taiwan, Republic of China.
Food Res Int. 2018 May;107:102-109. doi: 10.1016/j.foodres.2018.02.003. Epub 2018 Feb 7.
In this studied, extracts of black garlic on the improvement of gastrointestinal function, antioxidant activity, total polyphenols, total flavonoids and total polysaccharides were evaluated. Results showed that the black garlic n-butanol fraction extract (BA) had significantly increased effect within small intestine in vitro, while the ethyl acetate fractions had no significant effect on small intestine in vitro. Increase of 5-HT content effectively stimulated the gastrointestinal peristalsis, which enhanced its gastrointestinal tract emptying, and promoted defecation. As for antioxidant activity test, the water extract was more effective in SOD activity test, DPPH radical scavenging rates, ferric reducing antioxidant power and reducing power. In addition, the water fraction was simulated by gastric acid digestion and hydrolysis, and the small intestine was isolated after acid hydrolysis (AW). It was found that the water fraction extract after acid hydrolysis did significantly improve the intestinal contraction rate. In short, extract of black garlic could effectively promote gastrointestinal motility and promote defecation. The active compounds were highly polar ingredients since water extract of black garlic exhibits most significant effect on improving gastrointestinal function.
本研究评估了黑蒜提取物对胃肠道功能、抗氧化活性、总多酚、总黄酮和总多糖的改善作用。结果表明，黑蒜正丁醇提取物（BA）在体外对小肠有显著的促进作用，而乙酸乙酯部位对体外小肠无明显作用。5-HT 含量的增加有效刺激了胃肠道蠕动，促进了胃肠道排空，促进了排便。至于抗氧化活性测试，水提物在 SOD 活性测试、DPPH 自由基清除率、铁还原抗氧化能力和还原能力方面更有效。此外，通过胃酸消化和水解模拟水相，然后在酸水解后分离小肠（AW）。结果发现，酸水解后的水相提取物能显著提高小肠收缩率。总之，黑蒜提取物能有效促进胃肠蠕动，促进排便。活性化合物是高极性成分，因为黑蒜的水提物对改善胃肠道功能有最显著的作用。
