Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy; Research Unit in Affective and Social Neuroscience, Catholic University of the Sacred Heart, Milan, Italy.
Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy; Research Unit in Affective and Social Neuroscience, Catholic University of the Sacred Heart, Milan, Italy.
Psychiatry Res. 2018 Dec;270:974-980. doi: 10.1016/j.psychres.2018.03.041. Epub 2018 Mar 20.
Psychopathological components, such as reward sensitivity and impulsivity, and dopaminergic treatment are crucial characteristics related to the development of Pathological Gambling (PG) in Parkinson's Disease (PD). The aim of the present study is to investigate the differences in decision-making in PD patients with or without PG considering both neurophysiological and behavioral aspects. The IOWA Gambling Task (IGT) and electroencephalographic (EEG) activity were considered to elucidate the decision and post-feedback processes in PG. The sample included fifty-two PD patients, divided in three groups: 17 PD patients with active gambling behavior (PD Gamblers, PDG); 15 PD patients who remitted from PG (PD Non-Gamblers, PDNG); and a Control Group (CG) composed by 20 patients with PD only. EEG and IGT performance were recorded during decision and post-feedback phase. Results showed worse performance and an increase of the low frequency bands in the frontal area for the PDG group compared to the other two groups. In addition, higher BAS (Behavioral Activation System) and BIS-11 (Barratt Impulsiveness Scale) personality components were correlated to groups' behavioral response. These results show an anomalous behavioral (IGT) and cortical response of PDG patients related to their inability to use adequate control mechanisms during a decision-making task where reward mechanisms (BAS) and impulsivity (BIS-11) are relevant.
心理病理学成分，如奖励敏感性和冲动性，以及多巴胺能治疗，是与帕金森病（PD）中病理性赌博（PG）发展相关的关键特征。本研究的目的是研究考虑神经生理学和行为学方面的情况下，有无 PG 的 PD 患者在决策方面的差异。采用 Iowa 赌博任务（IGT）和脑电图（EEG）活动来阐明 PG 中的决策和反馈后过程。该样本包括 52 名 PD 患者，分为三组：17 名有活动性赌博行为的 PD 患者（PD 赌徒，PDG）；15 名 PG 缓解的 PD 患者（PD 非赌徒，PDNG）；和由 20 名仅患有 PD 的患者组成的对照组（CG）。在决策和反馈阶段记录了 EEG 和 IGT 的表现。结果表明，与其他两组相比，PDG 组的表现更差，前额区的低频带增加。此外，更高的 BAS（行为激活系统）和 BIS-11（巴雷特冲动量表）人格成分与组的行为反应相关。这些结果表明，PDG 患者在决策任务中表现出异常的行为（IGT）和皮质反应，这与他们在涉及奖励机制（BAS）和冲动性（BIS-11）的决策任务中无法使用适当的控制机制有关。
