Research Unit in Affective and Social Neuroscience Italy; Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy.
Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy.
Addict Behav. 2014 Jun;39(6):1026-32. doi: 10.1016/j.addbeh.2014.02.007. Epub 2014 Feb 20.
The current research explored the impact of cortical frontal asymmetry (left-lateralization effect) and Behavioral Activation System (BAS) on Substance Use Disorder (SUD) in decisional processes using the Iowa Gambling Task (IGT). Forty SUD participants and forty-two controls (CG) were tested using the IGT. Behavioral responses (gain/loss options), BIS/BAS scores and lateralized alpha band modulation (LTA) were considered. The SUD group increased the tendency to opt in favor of the immediate reward (loss strategy) more than the long-term option (win strategy) compared to the CG. Secondly, higher reward-subscale scores were observed in SUD. Thirdly, SUD showed an increase in left-hemisphere activation in response to losing (with immediate reward) choices in comparison with the CG. An imbalanced left hemispheric effect related to higher BAS trait could explain this "reward bias," because these components were found to explain (through the regression analysis) the main behavioral deficits.
当前的研究使用 Iowa 赌博任务（IGT）探索了皮质额侧不对称（左侧化效应）和行为激活系统（BAS）对决策过程中物质使用障碍（SUD）的影响。对 40 名 SUD 参与者和 42 名对照组（CG）进行了 IGT 测试。考虑了行为反应（收益/损失选项）、BIS/BAS 评分和偏侧化 alpha 波段调制（LTA）。与 CG 相比，SUD 组更倾向于选择即时奖励（损失策略），而不是长期选择（赢策略）。其次，SUD 组的奖励子量表评分较高。第三，与 CG 相比，SUD 在对失去（即时奖励）选择的反应中表现出左半球激活增加。与更高的 BAS 特质相关的不平衡的左半球效应可以解释这种“奖励偏见”，因为通过回归分析发现这些成分可以解释主要的行为缺陷。
