Khan A, Schall L M, Tur E, Maibach H I, Guy R H
Department of Dermatology, School of Medicine, University of California, San Francisco 94143.
Br J Dermatol. 1987 Aug;117(2):193-201. doi: 10.1111/j.1365-2133.1987.tb04116.x.
Laser Doppler velocimetry (LDV) was used to assess the effect of treatment upon cutaneous blood flow in psoriatic skin lesions. The resolution of two separate plaques in each of seven subjects was followed. Six of the subjects received the Goeckerman regimen, the seventh was treated with psoralen-ultraviolet A (PUVA) therapy. Control LDV readings were taken from uninvolved skin sites during the treatment period. Cutaneous blood flow in the psoriatic lesions of the Goeckerman-treated patients decreased to levels comparable to those in uninvolved skin early in the course of treatment and significantly preceeded the observed clinical resolution from 4 to 8 days after initiation of therapy (P less than 0.05). Visible flare-ups sometimes appeared when patients were untreated (over a weekend, for example) and these eruptions were accompanied by a transient elevation of LDV readings. Perfusion of the lesions of the PUVA-treated patient remained consistently higher than perfusion of uninvolved skin despite clinical healing. In a separate series of experiments, blood flow at the extensor surface of the forearm was measured in the skin of normal subjects, the uninvolved skin of psoriatic patients and the untreated lesional skin of psoriatic patients. While the lesional skin had significantly higher perfusion levels than uninvolved psoriatic or normal control skin (P less than 0.01), there was no significant difference between blood flow to the uninvolved psoriatic skin of psoriatics and that to the skin of healthy controls.
激光多普勒测速仪（LDV）用于评估治疗对银屑病皮损皮肤血流的影响。对7名受试者中每例的两块独立斑块的消退情况进行了跟踪。6名受试者接受了戈克曼疗法，第7名受试者接受了补骨脂素-紫外线A（PUVA）疗法。在治疗期间，从未受累的皮肤部位获取对照LDV读数。接受戈克曼疗法治疗的患者的银屑病皮损中的皮肤血流在治疗早期降至与未受累皮肤相当的水平，并且在开始治疗后4至8天显著先于观察到的临床消退（P小于0.05）。当患者未接受治疗时（例如在周末），有时会出现明显的皮疹复发，并且这些皮疹伴有LDV读数的短暂升高。尽管临床已愈合，但接受PUVA治疗的患者的皮损灌注始终高于未受累皮肤的灌注。在另一系列实验中，测量了正常受试者皮肤、银屑病患者未受累皮肤和银屑病患者未治疗的皮损皮肤在前臂伸侧表面的血流。虽然皮损皮肤的灌注水平显著高于未受累的银屑病或正常对照皮肤（P小于0.01），但银屑病患者未受累皮肤的血流与健康对照皮肤的血流之间没有显著差异。
