Staberg B, Klemp P
Acta Derm Venereol. 1984;64(4):331-34.
Skin blood flow (SBF) was measured by the laser Doppler technique in lesional and clinically normal skin of 8 patients with psoriasis vulgaris during Goeckerman or beech tar therapy. The SBF measurements were performed before therapy and 1, 2, and 3-4 weeks after treatment was initiated. The results were compared to a clinical psoriasis index based on the objective assessment of infiltration, erythema, and scaling of the psoriatic plaques. The pre-treatment value of SBF in lesional skin was about 9 times higher than that of clinically normal skin. During therapy SBF of involved skin decreased rapidly approaching that of uninvolved skin after 3-4 weeks. Furthermore, there was a significant linear correlation between the SBF values and the clinical psoriasis index. It is concluded that SBF in psoriatic lesions decreases significantly during Goeckerman or beech tar therapy, and that this variable might be used to obtain a quantitative measure of the disease activity.
采用激光多普勒技术，对8例寻常型银屑病患者在进行戈克曼疗法或山毛榉焦油疗法期间，其皮损处及临床正常皮肤的皮肤血流量（SBF）进行了测量。在治疗前以及开始治疗后的1、2和3 - 4周进行了SBF测量。将结果与基于银屑病斑块浸润、红斑和鳞屑的客观评估得出的临床银屑病指数进行了比较。皮损处皮肤SBF的治疗前值约为临床正常皮肤的9倍。在治疗期间，受累皮肤的SBF迅速下降，3 - 4周后接近未受累皮肤。此外，SBF值与临床银屑病指数之间存在显著的线性相关性。得出的结论是，在戈克曼疗法或山毛榉焦油疗法期间，银屑病皮损处的SBF显著降低，并且该变量可用于获得疾病活动度的定量测量。
