Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.
Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Physiology and Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Semin Fetal Neonatal Med. 2018 Aug;23(4):245-249. doi: 10.1016/j.siny.2018.03.008. Epub 2018 Mar 16.
The association between the patent ductus arteriosus (PDA) and neonatal morbidity, mortality and poor neurodevelopmental outcome in later childhood has been the focus of intense debate for decades. The lack of evidence supporting therapeutic strategies aimed at achieving PDA closure has led to the widespread adoption of conservative management aimed at mitigating the impact of shunt volume without achieving ductal closure. In this article, we review this management approach, describe the supportive evidence and potential complications associated with this strategy.
动脉导管未闭（PDA）与新生儿发病率、死亡率和儿童后期神经发育不良结局之间的关系几十年来一直是激烈争论的焦点。缺乏支持旨在实现 PDA 关闭的治疗策略的证据导致广泛采用保守管理策略，旨在减轻分流体积的影响而不实现导管关闭。在本文中，我们回顾了这种管理方法，描述了支持这种策略的证据和潜在并发症。
