Department of Pediatrics, Division of Pediatric Cardiology, Medical University of South Carolina, Charleston, SC, 29425, USA.
Department of Pediatrics, Division of Pediatric Nephrology, Medical University of South Carolina, Charleston, SC, 29425, USA.
J Perinatol. 2020 Mar;40(3):510-514. doi: 10.1038/s41372-019-0560-1. Epub 2019 Nov 25.
To investigate acute kidney injury (AKI) in neonates with a patent ductus arteriosus (PDA) including incidence, risk factors, and possible correlations between PDA-related echocardiographic measurements and AKI incidence.
We conducted a single-center retrospective cohort study of infants admitted to the neonatal intensive care unit with a diagnosis of a PDA between July 2015 and July 2017. Infants were evaluated for development of AKI based on the KDIGO criteria and a multivariable logistic regression analysis was performed.
A total of 142 neonates with moderate or large PDAs were included, 43 (30%) developed AKI. Patients who developed AKI had longer length of stay, lower birth weights, lengths, and gestational ages. No echocardiographic measurements were predictive of an increased risk for developing AKI.
There are no significant differences in commonly measured echocardiographic markers of PDA hemodynamic significance in neonates who develop AKI.
探讨动脉导管未闭（PDA）新生儿急性肾损伤（AKI）的发病情况、危险因素，以及与 PDA 相关的超声心动图测量值与 AKI 发病之间的可能相关性。
我们对 2015 年 7 月至 2017 年 7 月期间在新生儿重症监护病房（NICU）因 PDA 而住院的婴儿进行了一项单中心回顾性队列研究。根据 KDIGO 标准评估婴儿 AKI 的发生情况，并进行多变量逻辑回归分析。
共纳入 142 例中至大量 PDA 新生儿，其中 43 例（30%）发生 AKI。发生 AKI 的患儿住院时间更长，出生体重、身长和胎龄更低。没有超声心动图测量值可预测 AKI 发病风险增加。
在发生 AKI 的新生儿中，PDA 血流动力学意义的常见超声心动图指标无显著差异。
