Meyer P A
Department of Ophthalmology, Addenbrooke's Hospital, Cambridge.
Clin Exp Immunol. 1987 Jul;69(1):166-78.
Fluorescence microscopy of the conjunctival and episcleral circulations of the rabbit's eye has revealed for the first time the formation and deposition of intravascular and perivascular immune complexes in undisturbed capillaries in vivo. During intravascular immune complex formation, immune aggregates appear abruptly, at a critical antigen/antibody ratio, and embolize to the arterial side of the capillary bed. This is accompanied by a fall in the circulating platelet count. The emboli disperse over the ensuing 120 min. In frozen sections immune aggregates are coarsely granular and intraluminal at the moment they embolize. However, after they disperse, subendothelial granules of antigen can be found. IgG and C3 are associated with both intraluminal and subendothelial antigen. Perivascular immune complex formation is accompanied by an intense inflammatory response, which is absent after the deposition of an intravascular immune precipitate. The mechanism by which immune complexes may accomplish their transition across the capillary endothelium is discussed.
兔眼结膜和巩膜上循环的荧光显微镜检查首次揭示了体内未受干扰的毛细血管中血管内和血管周围免疫复合物的形成与沉积。在血管内免疫复合物形成过程中，免疫聚集体在临界抗原/抗体比例时突然出现，并栓塞到毛细血管床的动脉侧。这伴随着循环血小板计数的下降。栓塞在随后的120分钟内消散。在冰冻切片中，免疫聚集体在栓塞时呈粗颗粒状且位于管腔内。然而，在它们消散后，可以发现内皮下的抗原颗粒。IgG和C3与管腔内和内皮下的抗原都有关联。血管周围免疫复合物的形成伴随着强烈的炎症反应，而血管内免疫沉淀物沉积后则没有这种反应。文中讨论了免疫复合物跨越毛细血管内皮的可能机制。
