幼年类风湿关节炎患者自体混合淋巴细胞反应中OKT4抑制细胞的激活。
Activation of OKT4 suppressor cells in the autologous mixed lymphocyte reaction of patients with juvenile rheumatoid arthritis.
作者信息
Oen K, Krzekotowska D
机构信息
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
出版信息
Clin Exp Immunol. 1987 Jul;69(1):57-67.
Activation of suppressor cells by the autologous mixed lymphocyte reaction (AMLR) was studied in patients with juvenile rheumatoid arthritis (JRA). Isolated OKT4 cells were used as responders and irradiated whole non-T cell preparations, non-adherent non-T cells (B and null cells), adherent non-T cells (monocytes), and B cells preactivated by Staphylococcus aureus Cowan I, as stimulators in the AMLR. Suppression was assessed by a reduction of pokeweed mitogen stimulated immunoglobulin synthesis by lymphocytes of healthy donors upon addition of AMLR-activated OKT4 cells. The results of this study suggest normal activation of OKT4 suppressor cells in the AMLR of patients with JRA.
在青少年类风湿性关节炎（JRA）患者中研究了自体混合淋巴细胞反应（AMLR）对抑制细胞的激活作用。分离出的OKT4细胞用作反应细胞，并用经辐照的全非T细胞制剂、非贴壁非T细胞（B细胞和裸细胞）、贴壁非T细胞（单核细胞）以及经金黄色葡萄球菌Cowan I预激活的B细胞作为AMLR中的刺激细胞。通过在加入AMLR激活的OKT4细胞后，检测健康供体淋巴细胞对商陆有丝分裂原刺激的免疫球蛋白合成的减少来评估抑制作用。本研究结果提示JRA患者在AMLR中OKT4抑制细胞的激活正常。
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