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单克隆抗体所定义的人T细胞亚群的功能分析。IV. OKT4+群体内抑制细胞的诱导。

Functional analysis of human T cell subsets defined by monoclonal antibodies. IV. Induction of suppressor cells within the OKT4+ population.

作者信息

Thomas Y, Rogozinski L, Irigoyen O H, Friedman S M, Kung P C, Goldstein G, Chess L

出版信息

J Exp Med. 1981 Aug 1;154(2):459-67. doi: 10.1084/jem.154.2.459.

DOI:10.1084/jem.154.2.459
PMID:6455486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186430/
Abstract

In this report, we explored the functional heterogeneity within the OKT4+ subset of human T cells. Evidence was obtained that although in vitro pokeweed mitogen-activated OKT4+ cells can function as radioresistant helper cells, these activated OKT4+ cells could also exert potent feedback suppression. Despite the induction of suppressor cells after pokeweed mitogen activation, the OKT4+ population maintains its original OKT3+, OKT4+, nd OKT8- surface phenotype. The suppressor cells contained within the activated OKT4+ population were found to be radiosensitive. Importantly, the suppression mediated by activated OKT4+ cells required the presence of radiosensitive cells contained within the resting OKT4+ population. Taken together, these results suggest that the OKT4+ subset of human T cells contains cells that can be activated to differentiate into suppressor cells independent of OKT8+ cells.

摘要

在本报告中，我们探究了人T细胞OKT4+亚群内的功能异质性。有证据表明，虽然体外商陆有丝分裂原激活的OKT4+细胞可作为抗辐射辅助细胞发挥作用，但这些激活的OKT4+细胞也能发挥强大的反馈抑制作用。尽管商陆有丝分裂原激活后诱导出了抑制细胞，但OKT4+群体仍保持其原始的OKT3+、OKT4+和OKT8-表面表型。发现激活的OKT4+群体中所含的抑制细胞对辐射敏感。重要的是，激活的OKT4+细胞介导的抑制作用需要静止的OKT4+群体中所含的辐射敏感细胞的存在。综上所述，这些结果表明，人T细胞的OKT4+亚群包含可被激活以分化为抑制细胞的细胞，且该过程独立于OKT8+细胞。

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Functional analysis of human T cell subsets defined by monoclonal antibodies. IV. Induction of suppressor cells within the OKT4+ population.单克隆抗体所定义的人T细胞亚群的功能分析。IV. OKT4+群体内抑制细胞的诱导。
J Exp Med. 1981 Aug 1;154(2):459-67. doi: 10.1084/jem.154.2.459.
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Infect Immun. 1982 Oct;38(1):226-32. doi: 10.1128/iai.38.1.226-232.1982.
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In vitro effects of 4-hydroperoxycyclophosphamide on human immunoregulatory T subset function. I. Selective effects on lymphocyte function in T-B cell collaboration.4-氢过氧环磷酰胺对人免疫调节性T亚群功能的体外效应。I. 对T-B细胞协作中淋巴细胞功能的选择性效应。
J Exp Med. 1982 Jan 1;155(1):276-90. doi: 10.1084/jem.155.1.276.
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J Exp Med. 1981 Dec 1;154(6):1827-37. doi: 10.1084/jem.154.6.1827.
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Clin Exp Immunol. 1982 Aug;49(2):325-30.
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本文引用的文献

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Peripheral blood Ia-positive T cells. Increases in certain diseases and after immunization.外周血Ia阳性T细胞。在某些疾病及免疫后数量增加。
J Exp Med. 1980 Jan 1;151(1):91-100. doi: 10.1084/jem.151.1.91.
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Functional analysis of human T cell subsets defined by monoclonal antibodies. II. Collaborative T-T interactions in the generation of TNP-altered-self-reactive cytotoxic T lymphocytes.单克隆抗体所定义的人T细胞亚群的功能分析。II. TNP改变自身反应性细胞毒性T淋巴细胞产生中的T-T协作相互作用。
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Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative T-T interactions in the immunoregulation of B cell differentiation.由单克隆抗体定义的人T细胞亚群的功能分析。I. B细胞分化免疫调节中的T-T协作相互作用。
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Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage.人类胸腺内分化的离散阶段：T细胞系正常胸腺细胞和白血病淋巴母细胞的分析
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T cell requirements for generation of helper factor(s) in man: analysis of the subsets involved.人类中产生辅助因子的T细胞需求：对相关亚群的分析。
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Functional analysis of human T cell subsets defined by monoclonal antibodies. III. Regulation of helper factor production by T cell subsets.单克隆抗体所定义的人T细胞亚群的功能分析。III. T细胞亚群对辅助因子产生的调节。
J Immunol. 1981 May;126(5):1948-51.
7
A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2.一种单克隆抗体，可与人细胞毒性/抑制性T细胞亚群发生反应，该亚群先前由一种名为TH2的异种抗血清所定义。
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Immunologic functions of isolated human lymphocyte subpopulations. I. Quantitative isolation of human T and B cells and response to mitogens.分离的人淋巴细胞亚群的免疫功能。I. 人T细胞和B细胞的定量分离及对有丝分裂原的反应。
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Radiosensitivity of T and B lymphocytes. II. Effect of irradiation on response of T cells to alloantigens.T 淋巴细胞和 B 淋巴细胞的放射敏感性。II. 辐射对 T 细胞对抗原反应的影响。
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10
Antigen-secreting cells: enumeration of immunoglobulin-allotype-secreting cells in nonimmunized rabbits by means of hybrid-antibody-coated erythrocytes in a reverse hemolytic plaque assay.抗原分泌细胞：通过反向溶血空斑试验中杂交抗体包被的红细胞对未免疫兔中分泌免疫球蛋白同种异型的细胞进行计数。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1229-33. doi: 10.1073/pnas.71.4.1229.