Figueiredo A, Ribeiro C A, Gonçalo S, Caldeira M M, Poiares-Baptista A, Teixeira F
Department of Dermatology, University of Coimbra, Portugal.
Contact Dermatitis. 1987 Aug;17(2):73-9. doi: 10.1111/j.1600-0536.1987.tb02664.x.
During the last 3 years, 9 patients with a photosensitive eruption related to piroxicam therapy were seen. In all but one, it occurred within 4 days of first exposure to the drug. 7 patients required systemic corticosteroids, and 2 hospitalization. Clinical, histological and provocation studies were not conclusive in classifying the eruption as photoallergic or phototoxic. Experimental studies including photohaemolysis, Bacillus subtilis culture and nuclear magnetic resonance showed: (i) in irradiated piroxicam solutions, there was more haemolysis; (ii) in irradiated Petri dishes, piroxicam solutions showed greater inhibition of growth of B. subtilis; (iii) Piroxicam's NMR spectrum is not modified after irradiation. The results provide evidence of piroxicam phototoxic potential.
在过去3年里，共诊治了9例与吡罗昔康治疗相关的光敏性皮疹患者。除1例之外，所有患者均在首次接触该药物后的4天内发病。7例患者需要使用全身性皮质类固醇治疗，2例患者需要住院治疗。临床、组织学和激发试验在将该皮疹分类为光变应性或光毒性方面并无定论。包括光溶血、枯草芽孢杆菌培养和核磁共振在内的实验研究显示：（i）在经照射的吡罗昔康溶液中，溶血现象更明显；（ii）在经照射的培养皿中，吡罗昔康溶液对枯草芽孢杆菌生长的抑制作用更强；（iii）吡罗昔康的核磁共振谱在照射后未发生改变。这些结果为吡罗昔康的光毒性潜力提供了证据。
