Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Ophthalmol. 2018 Apr;66(4):591-593. doi: 10.4103/ijo.IJO_811_17.
We report a case of progressive outer retinal necrosis (PORN) in a patient of microscopic polyangitis (MPA), being treated with immunosuppressive drugs such as cyclophosphamide and rituximab. Her aqueous tap was positive for Varicella Zoster virus and she was treated with oral and intravitreal antivirals, along with discontinuation of one of the immunosuppressive agents, i.e. rituximab, which might have led to reactivation of the virus causing necrotizing retinitis lesions. Rituximab and cyclophosphamide are extremely potent drugs, which are necessary to manage immunological disorders such as MPA. However, they may predispose the patient to serious complications like viral infections, including PORN.
我们报告了一例微小多血管炎（MPA）患者发生进行性外层视网膜坏死（PORN）的病例，该患者正在接受免疫抑制剂治疗，如环磷酰胺和利妥昔单抗。她的房水穿刺液检测到水痘带状疱疹病毒呈阳性，因此接受了口服和玻璃体内抗病毒药物治疗，同时停用了一种免疫抑制剂，即利妥昔单抗，这可能导致病毒再次激活，引发坏死性视网膜炎病变。利妥昔单抗和环磷酰胺是非常有效的药物，对于治疗 MPA 等免疫性疾病是必要的。然而，它们可能使患者易患严重的并发症，如病毒感染，包括 PORN。
