Forster D J, Dugel P U, Frangieh G T, Liggett P E, Rao N A
Department of Ophthalmology, Doheny Eye Institute, University of Southern California School of Medicine, Los Angeles 90033.
Am J Ophthalmol. 1990 Oct 15;110(4):341-8. doi: 10.1016/s0002-9394(14)77012-6.
Two patients, both seropositive for the human immunodeficiency virus, developed rapidly progressive retinal necrosis associated with a systemic herpes zoster infection. The retinitis in these patients was characterized by primary involvement of the outer retina, with sparing of the inner retina and retinal vasculature until late in the disease process; a rapidly progressive course; poor response to intravenous acyclovir; and development of rhegmatogenous retinal detachment. In one of the patients, the retinitis was initially multifocal. Electron microscopy of a retinal biopsy specimen from one of the patients demonstrated virus particles consistent with a herpesvirus, and polymerase chain reaction disclosed herpesvirus in a retinal biopsy specimen of the other patient. This entity may represent a distinct form of acute retinal necrosis that is seen in immunocompromised individuals.
两名人类免疫缺陷病毒血清学阳性患者发生了与全身性带状疱疹感染相关的快速进展性视网膜坏死。这些患者的视网膜炎的特征为外层视网膜首先受累，内层视网膜和视网膜血管在疾病过程后期才受累；病程进展迅速；对静脉注射阿昔洛韦反应不佳；以及发生孔源性视网膜脱离。其中一名患者的视网膜炎最初为多灶性。对其中一名患者的视网膜活检标本进行电子显微镜检查发现了与疱疹病毒一致的病毒颗粒，聚合酶链反应在另一名患者的视网膜活检标本中检测到了疱疹病毒。这种病症可能代表了在免疫功能低下个体中出现的一种独特的急性视网膜坏死形式。
