Norman T, Chiu E, James R H, Gregory M S
Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Eur J Clin Pharmacol. 1987;32(6):583-6. doi: 10.1007/BF02455992.
The pharmacokinetic properties of a single oral dose of 100 mg of tiapride were studied in six patients with Huntington's disease. The results for five patients were consistent with a two compartment open model. Peak plasma concentrations were observed within 2 h following drug administration with a mean value of 0.92 micrograms/ml being recorded. The drug was rapidly eliminated as unmetabolised tiapride in the urine, 51% of the dose was recovered in 24 h. The plasma elimination half-life was 5.3 h and the average apparent plasma clearance was 16.6 l/h.
对6名患有亨廷顿舞蹈症的患者研究了单次口服100毫克硫必利的药代动力学特性。5名患者的结果符合二室开放模型。给药后2小时内观察到血浆浓度峰值，记录的平均值为0.92微克/毫升。药物以未代谢的硫必利形式迅速经尿液排出，24小时内回收了51%的给药剂量。血浆消除半衰期为5.3小时，平均表观血浆清除率为16.6升/小时。
