硫必利治疗左旋多巴诱发的不自主运动。
Tiapride in levodopa-induced involuntary movements.
作者信息
Lees A J, Lander C M, Stern G M
出版信息
J Neurol Neurosurg Psychiatry. 1979 Apr;42(4):380-3. doi: 10.1136/jnnp.42.4.380.
Abstract
Tiapride, a substituted benzamide derivative closely related to metoclopramide, reduced levodopa-induced peak dose involuntary movements in 16 patients with idiopathic Parkinson's disease. However, an unacceptable increase in disability from Parkinsonism with aggravation of end-of-dose akinesia led to its cessation in 14 patients. Tiapride had no effect on levodopa-induced early morning of "off-period" segmental dystonia. These results fail to support the notion that levodopa-induced dyskinesias are caused by overstimulation of a separate group of dopamine receptors.
摘要
硫必利是一种与甲氧氯普胺密切相关的取代苯甲酰胺衍生物，可减少16例特发性帕金森病患者左旋多巴诱导的峰值剂量不自主运动。然而，14例患者因帕金森病导致的残疾不可接受地增加，且剂量末期运动不能加重，导致该药停用。硫必利对左旋多巴诱导的清晨“关期”节段性肌张力障碍无效。这些结果不支持左旋多巴诱导的运动障碍是由另一组多巴胺受体过度刺激引起的这一观点。
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本文引用的文献
1
Attempted use of haloperidol in the treatment of L-dopa induced dyskinesias.尝试使用氟哌啶醇治疗左旋多巴诱发的运动障碍。
J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):427-30. doi: 10.1136/jnnp.37.4.427.
2
Metoclopramide--side effects and safety.甲氧氯普胺——副作用与安全性
Postgrad Med J. 1973 Jul;49 Suppl 4:suppl 4:77-80.
3
Heterogeneity of striatal and limbic dopamine innervation: highly fluorescent islands in developing and adult rats.纹状体和边缘系统多巴胺神经支配的异质性：发育中和成年大鼠中的高荧光岛
Brain Res. 1972 Sep 15;44(1):283-8. doi: 10.1016/0006-8993(72)90385-x.
4
The action of dopamine on neurones of the caudate nucleus.多巴胺对尾状核神经元的作用。
J Physiol. 1967 Apr;189(3):393-402. doi: 10.1113/jphysiol.1967.sp008175.
5
Metoclopramide and pimozide in Parkinson's disease and levodopa-induced dyskinesias.胃复安和匹莫齐特在帕金森病及左旋多巴诱发的异动症中的应用
J Neurol Neurosurg Psychiatry. 1975 Apr;38(4):331-5. doi: 10.1136/jnnp.38.4.331.
6
Effect of new dopamine-blocking agent (oxiperomide) on drug-induced dyskinesias in Parkinson's disease and spontaneous dyskinesias.新型多巴胺阻断剂（奥昔哌隆）对帕金森病药物诱发的运动障碍和自发性运动障碍的影响。
Br Med J. 1978 Apr 15;1(6118):954-6. doi: 10.1136/bmj.1.6118.954.
7
Tardive dyskinesia associated with metoclopramide.与甲氧氯普胺相关的迟发性运动障碍。
Br Med J. 1978 Jan 14;1(6105):77-8. doi: 10.1136/bmj.1.6105.77.
8
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9
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10
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Psychopharmacologia. 1976 Feb 2;45(3):243-54. doi: 10.1007/BF00421135.
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