Saalmüller A, Reddehase M J, Bühring H J, Jonjić S, Koszinowski U H
Federal Research Centre for Virus Diseases of Animals, Tübingen, FRG.
Eur J Immunol. 1987 Sep;17(9):1297-301. doi: 10.1002/eji.1830170912.
The existence of four subpopulations in resting porcine T lymphocytes is documented. In addition to the two known subpopulations which are typified by a mutually exclusive expression of either the CD8 or the CD4 differentiation antigen, CD4-CD8+ and CD4+CD8- T lymphocytes, respectively, two unusual subpopulations were prominent not only in peripheral blood, but also in lymphoid tissues: CD4-CD8- T lymphocytes expressing neither of these antigens and CD4+CD8+ T lymphocytes coexpressing both antigens. While CD4+CD8+ lymphoblasts have been found also in other species, resting T lymphocytes with that phenotype are without precedent among all species analyzed to date. This unique composition of the porcine T lymphocyte population has to be taken into consideration when the swine is used as a large animal model in experimental medicine.
已证实静息猪T淋巴细胞中存在四个亚群。除了两个已知的亚群，即以分别互斥表达CD8或CD4分化抗原为特征的CD4-CD8+和CD4+CD8-T淋巴细胞外，两个不寻常的亚群不仅在外周血中很突出，在淋巴组织中也很突出：既不表达这两种抗原的CD4-CD8-T淋巴细胞和同时表达这两种抗原的CD4+CD8+T淋巴细胞。虽然在其他物种中也发现了CD4+CD8+淋巴母细胞，但在迄今为止分析的所有物种中，具有该表型的静息T淋巴细胞尚无先例。当猪被用作实验医学中的大型动物模型时，必须考虑猪T淋巴细胞群体的这种独特组成。
