Asanov A Iu, Ginter E K, Bakhramov S M, Gar'kavtseva R F, Revazov A A
Genetika. 1987 Jul;23(7):1328-33.
It was shown that on comparing variability of selective neutral genetic marker systems with that of the beta-thalassemia system for the populations of different hierarchical level, the relative importance of selection and genetic drift could be evaluated. The genetic differentiation of the beta-thalassemia gene frequencies in elementary populations (villages) could be solely explained by genetic drift. On the other hand, the differentiation of district populations (the sizes of the populations being 10(6] for beta-thalassemia gene frequencies could be explained by selection forces. This is supported by the fact that the genetic distances and FST values are only significant for the beta-thalassemia gene and not for the neutral genetic systems, when the district populations are compared.
结果表明，在比较不同层次水平人群的选择性中性遗传标记系统和β地中海贫血系统的变异性时，可以评估选择和遗传漂变的相对重要性。基层人群（村庄）中β地中海贫血基因频率的遗传分化完全可以用遗传漂变来解释。另一方面，地区人群（人群规模为10^6）中β地中海贫血基因频率的分化可以用选择力来解释。当比较地区人群时，遗传距离和FST值仅对β地中海贫血基因有显著意义，而对中性遗传系统没有显著意义，这一事实支持了这一点。
