[土库曼斯坦人群的医学遗传学研究。IV. 血红蛋白病的群体地理学]
[Medico-genetic study of the population of Turkmenia. IV. The population geography of hemoglobinopathies].
作者信息
Turaeva Sh M, Ginter E K, Revazov A A, Gar'kavtseva R F, Kiiatkhanov B A
出版信息
Genetika. 1984 Sep;20(9):1536-41.
Large-scale screening for hereditary haemoglobinopathies in five districts and among main Turkmen tribes was carried out. The frequencies of ABO and HP pheno- and genotypes were determined in the same populations. The different kinds of haemoglobinopathies genes were discovered (beta +, beta 0-thalassemia, alpha beta-thalassemia, alpha-thalassemia, HPFH, haemoglobins D and E). The geographic and ethnic differentiation of Turkmen population for beta-thalassemia géne was discovered. The FST values were found to be the same for ABO, Hp and beta-thal gene systems. The role of genetic drift in differentiation of Turkmen population is discussed.
对五个地区以及主要土库曼部落进行了遗传性血红蛋白病的大规模筛查。在相同人群中确定了ABO和HP表型及基因型的频率。发现了不同类型的血红蛋白病基因（β+、β0-地中海贫血、αβ-地中海贫血、α-地中海贫血、遗传性胎儿血红蛋白持续存在症、血红蛋白D和E）。发现了土库曼人群中β-地中海贫血基因的地理和种族差异。发现ABO、Hp和β-地中海贫血基因系统的FST值相同。讨论了遗传漂变在土库曼人群分化中的作用。
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