Frosch P J, Raulin C
Universitäts-Hautklinik Heidelberg.
Hautarzt. 1987 Jun;38(6):331-4.
Thirteen cases of contact allergy to bufexamac have been seen since 1976 at the Department of Dermatology of the University of Heidelberg. Most of the patients were women (69%). Nine patients suffered from chronic eczema and four had stasis dermatitis. Four patients had used bufexamac for less than 2 weeks. Based on the case histories, about half of the patients were suspected of having contact allergy to bufexamac. The clinical picture was consistent with that of allergic contact dermatitis; a generalized eruption was observed in two cases. Eight patients had additional sensitizations; three patients were allergic to benzyl alcohol, which is used as a preservative in the bufexamac cream available commercially. Contact allergy to bufexamac seems to be rare; however, it should be considered as a cause of sensitization in patients with chronic eczema, even after short-term application.
自1976年以来，海德堡大学皮肤科已发现13例对丁苯羟酸的接触性过敏病例。大多数患者为女性（69%）。9例患者患有慢性湿疹，4例患有淤积性皮炎。4例患者使用丁苯羟酸的时间不足2周。根据病历，约半数患者被怀疑对丁苯羟酸有接触性过敏。临床表现与过敏性接触性皮炎相符；2例出现全身性皮疹。8例患者有其他致敏情况；3例患者对苯甲醇过敏，苯甲醇在市售丁苯羟酸乳膏中用作防腐剂。对丁苯羟酸的接触性过敏似乎很少见；然而，即使是短期使用，也应将其视为慢性湿疹患者致敏的一个原因。
