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1
Activated RecA protein may induce expression of a gene that is not controlled by the LexA repressor and whose function is required for mutagenesis and repair of UV-irradiated bacteriophage lambda.活化的RecA蛋白可能诱导一个基因的表达，该基因不受LexA阻遏物的控制，其功能对于紫外线照射的λ噬菌体的诱变和修复是必需的。
J Bacteriol. 1987 Oct;169(10):4816-21. doi: 10.1128/jb.169.10.4816-4821.1987.
2
Weigle reactivation and mutagenesis of bacteriophage lambda in lexA(Def) mutants of E. coli K12.在大肠杆菌K12的lexA（缺陷型）突变体中噬菌体λ的韦格尔激活与诱变
Mol Gen Genet. 1985;201(2):329-33. doi: 10.1007/BF00425679.
3
Dual role for Escherichia coli RecA protein in SOS mutagenesis.大肠杆菌RecA蛋白在SOS诱变中的双重作用。
Proc Natl Acad Sci U S A. 1985 May;82(10):3325-9. doi: 10.1073/pnas.82.10.3325.
4
"Activated"-RecA protein affinity chromatography of LexA repressor and other SOS-regulated proteins.LexA阻遏蛋白及其他SOS调控蛋白的“活化”RecA蛋白亲和层析法
Proc Natl Acad Sci U S A. 1989 Nov;86(21):8363-7. doi: 10.1073/pnas.86.21.8363.
5
Novel mechanism for UV sensitivity and apparent UV nonmutability of recA432 mutants: persistent LexA cleavage following SOS induction.recA432突变体对紫外线敏感及明显的紫外线不可突变性的新机制：SOS诱导后LexA持续切割
J Bacteriol. 1993 Nov;175(22):7373-82. doi: 10.1128/jb.175.22.7373-7382.1993.
6
Analysis of Escherichia coli RecA interactions with LexA, lambda CI, and UmuD by site-directed mutagenesis of recA.通过recA的定点诱变分析大肠杆菌RecA与LexA、λCI和UmuD的相互作用。
J Bacteriol. 2000 Mar;182(6):1659-70. doi: 10.1128/JB.182.6.1659-1670.2000.
7
Regulation of the SOS response in Bacillus subtilis: evidence for a LexA repressor homolog.枯草芽孢杆菌中SOS反应的调控：LexA阻遏物同源物的证据。
J Bacteriol. 1991 Oct;173(20):6489-98. doi: 10.1128/jb.173.20.6489-6498.1991.
8
Intramolecular cleavage of LexA and phage lambda repressors: dependence of kinetics on repressor concentration, pH, temperature, and solvent.LexA和噬菌体λ阻遏物的分子内切割：动力学对阻遏物浓度、pH值、温度和溶剂的依赖性。
Biochemistry. 1986 Nov 4;25(22):6866-75. doi: 10.1021/bi00370a020.
9
Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: evidence for the requirement for the dinB gene.RecA蛋白在噬菌体λ非靶向紫外线诱变中的作用：dinB基因需求的证据
Proc Natl Acad Sci U S A. 1986 Jun;83(11):3904-8. doi: 10.1073/pnas.83.11.3904.
10
Cleavage of lambda repressor and synthesis of RecA protein induced by transferred UV-damaged F sex factor.转移的紫外线损伤F性因子诱导λ阻遏物的裂解和RecA蛋白的合成。
Mol Gen Genet. 1982;186(2):170-9. doi: 10.1007/BF00331847.

引用本文的文献

1
New complexities of SOS-induced "untargeted" mutagenesis in Escherichia coli as revealed by mutation accumulation and whole-genome sequencing.SOS 诱导的“非靶向”大肠杆菌突变累积和全基因组测序揭示的新复杂性。
DNA Repair (Amst). 2020 Jun;90:102852. doi: 10.1016/j.dnarep.2020.102852. Epub 2020 Apr 18.
2
The SOS Regulatory Network.SOS调控网络。
EcoSal Plus. 2008 Jul 25;2008. doi: 10.1128/ecosalplus.5.4.3.
3
Characterization of dinY, a new Escherichia coli DNA repair gene whose products are damage inducible even in a lexA(Def) background.dinY的特性研究，dinY是大肠杆菌中的一个新的DNA修复基因，其产物即使在lexA(Def)背景下也是损伤诱导型的。
J Bacteriol. 1993 Feb;175(3):642-6. doi: 10.1128/jb.175.3.642-646.1993.
4
Nature of the SOS mutator activity: genetic characterization of untargeted mutagenesis in Escherichia coli.SOS诱变活性的本质：大肠杆菌中非靶向诱变的遗传特征分析
Mol Gen Genet. 1988 Aug;213(2-3):491-8. doi: 10.1007/BF00339621.
5
Genetic control of AAF-induced mutagenesis at alternating GC sequences: an additional role for RecA.在交替的GC序列处AAF诱导的诱变的遗传控制：RecA的另一个作用。
Mol Gen Genet. 1989 Jan;215(2):306-11. doi: 10.1007/BF00339733.
6
DNA damage-inducible loci in Salmonella typhimurium.鼠伤寒沙门氏菌中的DNA损伤诱导位点。
J Bacteriol. 1991 Jun;173(11):3587-90. doi: 10.1128/jb.173.11.3587-3590.1991.
7
Genetic evidence for an activator required for induction of pectin lyase in Erwinia carotovora subsp. carotovora by DNA-damaging agents.胡萝卜软腐欧文氏菌胡萝卜软腐亚种中DNA损伤剂诱导果胶裂解酶所需激活剂的遗传证据。
J Bacteriol. 1992 Aug;174(16):5471-4. doi: 10.1128/jb.174.16.5471-5474.1992.
8
New mutations in and around the L2 disordered loop of the RecA protein modulate recombination and/or coprotease activity.RecA蛋白L2无序环及其周围的新突变调节重组和/或共蛋白酶活性。
J Bacteriol. 1992 Oct;174(19):6264-9. doi: 10.1128/jb.174.19.6264-6269.1992.
9
Inhibition of the recBCD-dependent activation of Chi recombinational hot spots in SOS-induced cells of Escherichia coli.在大肠杆菌SOS诱导细胞中对recBCD依赖性Chi重组热点激活的抑制作用。
J Bacteriol. 1992 Feb;174(4):1172-8. doi: 10.1128/jb.174.4.1172-1178.1992.

本文引用的文献

1
Induction of Mutations in a Bacterial Virus.细菌病毒中突变的诱导
Proc Natl Acad Sci U S A. 1953 Jul;39(7):628-36. doi: 10.1073/pnas.39.7.628.
2
An immunoradiometric quantitative assay of Escherichia coli recA protein.
Biochimie. 1982 Apr;64(4):239-46. doi: 10.1016/s0300-9084(82)80490-2.
3
Inducibility of a gene product required for UV and chemical mutagenesis in Escherichia coli.大肠杆菌中紫外线和化学诱变所需基因产物的可诱导性。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5749-53. doi: 10.1073/pnas.78.9.5749.
4
Influence of RecA protein on induced mutagenesis.RecA蛋白对诱导突变的影响。
Biochimie. 1982 Aug-Sep;64(8-9):633-6. doi: 10.1016/s0300-9084(82)80102-8.
5
Isolation and characterization of an operator-constitutive mutation in the recA gene of E. coli K-12.大肠杆菌K-12 recA基因中一个操纵子组成型突变的分离与鉴定。
Mol Gen Genet. 1982;187(1):4-11. doi: 10.1007/BF00384376.
6
The genetics and regulation of heat-shock proteins.热休克蛋白的遗传学与调控
Annu Rev Genet. 1984;18:295-329. doi: 10.1146/annurev.ge.18.120184.001455.
7
The SOS regulatory system: control of its state by the level of RecA protease.SOS调控系统：由RecA蛋白酶水平对其状态进行控制。
J Mol Biol. 1983 Jul 15;167(4):791-808. doi: 10.1016/s0022-2836(83)80111-9.
8
Involvement of the activated form of RecA protein in SOS mutagenesis and stable DNA replication in Escherichia coli.RecA蛋白的活化形式参与大肠杆菌中的SOS诱变和稳定DNA复制。
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7539-43. doi: 10.1073/pnas.81.23.7539.
9
Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.大肠杆菌中的诱变作用及对脱氧核糖核酸损伤的诱导反应
Microbiol Rev. 1984 Mar;48(1):60-93. doi: 10.1128/mr.48.1.60-93.1984.
10
Role of the E. coli umuC gene product in the repair of single-stranded DNA phage.大肠杆菌umuC基因产物在单链DNA噬菌体修复中的作用。
Mol Gen Genet. 1983;192(3):509-11. doi: 10.1007/BF00392198.

活化的RecA蛋白可能诱导一个基因的表达，该基因不受LexA阻遏物的控制，其功能对于紫外线照射的λ噬菌体的诱变和修复是必需的。

Activated RecA protein may induce expression of a gene that is not controlled by the LexA repressor and whose function is required for mutagenesis and repair of UV-irradiated bacteriophage lambda.

作者信息

Calsou P, Villaverde A, Defais M

机构信息

Laboratoire de Pharmacologie et de Toxicologie Fondamentales, Toulouse, France.

出版信息

J Bacteriol. 1987 Oct;169(10):4816-21. doi: 10.1128/jb.169.10.4816-4821.1987.

DOI:10.1128/jb.169.10.4816-4821.1987
PMID:2958446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC213860/
Abstract

The activated form of the RecA protein (RecA) is known to be involved in the reactivation and mutagenesis of UV-irradiated bacteriophage lambda and in the expression of the SOS response in Escherichia coli K-12. The expression of the SOS response requires cleavage of the LexA repressor by RecA and the subsequent expression of LexA-controlled genes. The evidence presented here suggests that RecA induces the expression of a gene(s) that is not under LexA control and that is also necessary for maximal repair and mutagenesis of damaged phage. This conclusion is based on the chloramphenicol sensitivity of RecA -dependent repair and mutagenesis of damaged bacteriophage lambda in lexA(Def) hosts.

摘要

已知RecA蛋白的活化形式（RecA）参与紫外线照射的噬菌体λ的再活化和诱变，以及大肠杆菌K-12中SOS应答的表达。SOS应答的表达需要RecA切割LexA阻遏物以及随后LexA控制基因的表达。此处提供的证据表明，RecA诱导一个不受LexA控制的基因的表达，该基因对于受损噬菌体的最大程度修复和诱变也是必需的。这一结论基于lexA（Def）宿主中RecA依赖性修复和受损噬菌体λ诱变对氯霉素的敏感性。