Division of Biobank for Health Sciences, Center for Genome Science, Korea National Institute of Health , Korea Centers for Disease Control and Prevention, Cheongju-si, Korea.
OMICS. 2018 Apr;22(4):255-263. doi: 10.1089/omi.2017.0197. Epub 2018 Mar 27.
Biobanks are infrastructures for large-scale biology innovation. Governance of biobanks can be usefully informed by studies of publication trends, for example, on the types of biosamples employed in scientific publications. We examined trends in each of the serum, plasma, peripheral blood mononuclear cell (PBMC), buffy coat, tissue, and gut microbiome biosample-related scientific publications over the past 40 years, using data between 1977 and 2016 from the Scopus database. We found that the number of tissue-related publications was the highest in each year of our analysis than other biosamples, but was generally less than the sum of serum- and plasma-related publications. Importantly, the microbiome publications increased greatly starting in the 2010s, and currently overtook the number of publications on PBMC and buffy coat. Among serum-, plasma-, and tissue-related publications, the number of protein- and RNA-related publications was generally higher than cell-free DNA-, DNA-, and metabolite-related publications for the past 40 years. Mass spectrometry- and next-generation sequencing-related publications have increased dramatically since the 2000s and 2010s, respectively. Microbiome- and metabolite-related biosamples can help diversify future biosample collections, while tissue collections appear to maintain their importance in scientific publications. We also report here our observations on the countries that use biosample research (e.g., China, United Kingdom, United States, and others). These publication trends by the type of biosamples illuminate roadmaps by which biobanks might establish and diversify their biosample collections in the future. In addition, we note that biobanks need to secure biosamples appropriate for integrated analysis of multi-omics research data.
生物银行是大规模生物学创新的基础设施。通过研究出版物趋势，例如科学出版物中使用的生物样本类型，生物银行的治理可以得到有益的指导。我们利用 Scopus 数据库在 1977 年至 2016 年之间的数据，检查了过去 40 年来血清、血浆、外周血单核细胞 (PBMC)、白细胞层、组织和肠道微生物组生物样本相关科学出版物的趋势。我们发现，在我们分析的每一年，与组织相关的出版物数量都高于其他生物样本，但通常低于与血清和血浆相关的出版物数量之和。重要的是，从 21 世纪 10 年代开始，微生物组出版物数量大幅增加，目前已超过 PBMC 和白细胞层相关出版物的数量。在血清、血浆和组织相关出版物中，过去 40 年来，与蛋白质和 RNA 相关的出版物数量通常高于与无细胞 DNA、DNA 和代谢物相关的出版物数量。自 2000 年代和 21 世纪 10 年代以来，质谱和下一代测序相关出版物分别大幅增加。微生物组和代谢组相关生物样本可以帮助未来的生物样本收集多样化，而组织收集在科学出版物中似乎仍然保持着重要地位。我们还在此报告了我们对使用生物样本研究的国家（例如中国、英国、美国等）的观察结果。这些生物样本类型的出版物趋势阐明了生物库在未来建立和多样化其生物样本收集的路线图。此外，我们注意到生物库需要确保有适合多组学研究数据综合分析的生物样本。
