Department of Cognitive Science, Psychological, Education and Cultural Studies, University of Messina, Italy.
St. Vincent's Hospital and Medical Center Portland, OR, United States.
Res Dev Disabil. 2018 May;76:76-87. doi: 10.1016/j.ridd.2018.03.008. Epub 2018 Mar 26.
this study was based on both neurophysiological decelerated activity and communication deficits in Rett Syndrome (RTT).
the aim was to examine the neurophysiological and cognitive effects of Transcranial Direct Current Stimulation (tDCS) in three girls with RTT with chronic language impairments.
we proposed an integrated intervention: tDCS and cognitive empowerment applied to language in order to enhance speech production (new functional sounds and new words). Because maximal gains usually are achieved when tDCS is coupled with behavioral training, we applied tDCS stimulation on Broca's area together with linguistic training.
the results indicated a general enhancement in language abilities (an increase in the number of vowel/consonant sounds and words and the production and comprehension through discrimination), motor coordination (functional movements), and neurophysiological parameters (an increase in the frequency and power of alpha, beta and theta bands).
we assume that tDCS stimulation combined with the cognitive empowerment applied to language can significantly influence a chronic impairment even in genetic syndromes. Our results provide data that support the role of tDCS in fostering brain plasticity and in particular in empowering speech production and comprehension in girls with RTT.
本研究基于雷特综合征（RTT）的神经生理学减速活动和交流障碍。
目的是检查经颅直流电刺激（tDCS）对 3 名患有慢性语言障碍的 RTT 女孩的神经生理学和认知影响。
我们提出了一种综合干预措施：tDCS 和认知增强应用于语言，以增强言语产生（新的功能声音和新单词）。因为当 tDCS 与行为训练结合时通常会获得最大收益，所以我们在布洛卡区施加 tDCS 刺激，同时进行语言训练。
结果表明语言能力普遍提高（元音/辅音声音和单词的数量增加，通过辨别产生和理解）、运动协调（功能性运动）和神经生理学参数（α、β和θ频段的频率和功率增加）。
我们假设 tDCS 刺激与应用于语言的认知增强相结合，可以显著影响慢性障碍，即使在遗传综合征中也是如此。我们的结果提供了支持 tDCS 在促进大脑可塑性中的作用的数据，特别是在增强 RTT 女孩的言语产生和理解方面。
