Department of Clinical Biochemistry, Rigshospitalet, Valdemar Hansens Vej 13, DK-2600 Glostrup, Denmark; OPEN, Odense Patient data Explorative Network, Odense University Hospital/Institute of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 9, DK-5000 Odense C, Denmark.
Curr Opin Immunol. 2018 Jun;52:32-38. doi: 10.1016/j.coi.2018.03.016. Epub 2018 Mar 26.
A strong skeleton relies on adaptation to varying physical demands and on maintenance of the bone tissue in order to avoid accumulation of micro-damage. In bone, the purinergic P2X7 ion channel receptor is expressed on both cells of the stromal lineage such as the bone forming osteoblasts and the mechano-sensing osteocytes and on cells belonging to the immune-related monocyte-macrophage lineage, the bone resorbing osteoclasts. Recent studies have demonstrated that the receptor plays important roles in the anabolic responses to mechanical loading on bone and, together with the pannexin1 hemi-channel, in the process of initiating bone remodeling in response to micro-damage. Thus, the receptor is crucial in skeletal mechano-transduction and in the continuous repair process. However, under pathophysiological conditions such as diabetes with high glucose concentrations or glucocorticoid-treatment the receptor is downregulated thus blunting the important effects it has for maintaining a healthy and strong skeleton.
强壮的骨骼依赖于适应不同的物理需求以及维持骨组织，以避免微损伤的积累。在骨骼中，嘌呤能 P2X7 离子通道受体表达于基质谱系的细胞，如成骨细胞和机械敏感的破骨细胞，以及属于免疫相关单核细胞-巨噬细胞谱系的细胞，即破骨细胞。最近的研究表明，该受体在骨对机械加载的合成反应中发挥重要作用，并且与连接蛋白 1 半通道一起，在响应微损伤启动骨重塑的过程中发挥重要作用。因此，该受体对于骨骼机械转导和持续修复过程至关重要。然而，在病理生理条件下，如高血糖浓度的糖尿病或糖皮质激素治疗，该受体下调，从而削弱了其对维持健康强壮骨骼的重要作用。
