General Internal Medicine 2, General Medical Center, Kawasaki Medical School, Okayama, Japan.
Department of Health Care Medicine, Kawasaki Medical School, Okayama, Japan.
Digestion. 2018;97(4):340-344. doi: 10.1159/000485734. Epub 2018 Mar 27.
Gastrin acts physiologically as a gut hormone to stimulate acid secretion after meal and as a cell-growth factor of oxyntic mucosa. Increase in serum gastrin level happens under various conditions including Zollinger-Ellison syndrome, antral G cell hyperplasia, autoimmune gastritis, atrophic gastritis, renal failure, vagotomy, Helicobacter pylori infection and acid suppressive therapy. As acid suppressive therapy causes hypergastrinemia, the association between acid suppressive therapy and gastric neuroendocrine cell tumor (NET) has been discussed during the past 30 years. In this review article, the definition of hypergastrinemia and the related disorders including acid suppressive therapy and gastric NET are discussed.
胃泌素在生理上作为一种肠道激素，在餐后刺激胃酸分泌，作为胃黏膜的细胞生长因子。在各种情况下，包括 Zollinger-Ellison 综合征、胃窦 G 细胞增生、自身免疫性胃炎、萎缩性胃炎、肾衰竭、迷走神经切断术、幽门螺杆菌感染和抑酸治疗，血清胃泌素水平都会升高。由于抑酸治疗会导致高胃泌素血症，因此在过去 30 年中，人们一直在讨论抑酸治疗与胃神经内分泌肿瘤（NET）之间的关系。在这篇综述文章中，我们讨论了高胃泌素血症的定义以及包括抑酸治疗和胃 NET 在内的相关疾病。
