Kang Seung-Gul, Lee Heon-Jeong, Choi Jung-Eun, Park Jae-Hong, Lee Sang-Shin, Han Changsu, Kim Yong-Ku, Kim Seung-Hyun, Lee Min-Soo, Joe Sook-Haeng, Jung In-Kwa, Kim Leen
1Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea.
3Department of Psychiatry, National Bugok Hospital, Gyeongsangnam-do, South Korea.
Acta Neuropsychiatr. 2007 Dec;19(6):351-6. doi: 10.1111/j.1601-5215.2007.00240.x.
The incidence of restless legs syndrome (RLS) is presumed to be higher among people with schizophrenia who take antipsychotic medication, most of which blocks the dopamine D2 receptor. The purpose of this study was to determine whether the G-protein β3 subunit (GNB3) C825T polymorphism is associated with antipsychotic-induced RLS in schizophrenia.
We examined 178 Korean patients with schizophrenia. All of the subjects were evaluated using the diagnostic criteria of the International Restless Legs Syndrome Study Group and the International Restless Legs Scale. Genotyping was performed for the C825T polymorphism in the GNB3 gene.
The genotype distribution did not differ significantly between antipsychotic-induced RLS patients and patients who had no-RLS symptoms (χ 2 = 4.30, p = 0.116). The genotypes of the C825T single-nucleotide polymorphism (SNP) were classified into two groups: C+ (CC and CT genotypes) and C- (TT genotype). The presence of the C allele (C+) was associated with an increased likelihood of RLS (χ 2 = 4.14, p = 0.042; odds ratio = 2.56, 95% confidence interval = 1.02-6.47).
These results suggest that the GNB3 C825T SNP is associated with RLS in schizophrenia. However, confirming this association requires future larger scale studies in which the effects of medication are strictly controlled.
据推测，服用抗精神病药物的精神分裂症患者中不安腿综合征（RLS）的发病率较高，其中大多数抗精神病药物会阻断多巴胺D2受体。本研究的目的是确定G蛋白β3亚基（GNB3）C825T多态性是否与精神分裂症患者中抗精神病药物诱发的RLS相关。
我们对178例韩国精神分裂症患者进行了检查。所有受试者均根据国际不安腿综合征研究组的诊断标准和国际不安腿量表进行评估。对GNB3基因的C825T多态性进行基因分型。
抗精神病药物诱发的RLS患者与无RLS症状的患者之间的基因型分布无显著差异（χ2 = 4.30，p = 0.116）。C825T单核苷酸多态性（SNP）的基因型分为两组：C+（CC和CT基因型）和C-（TT基因型）。C等位基因（C+）的存在与RLS的发生可能性增加相关（χ2 = 4.14，p = 0.042；优势比 = 2.56，95%置信区间 = 1.02 - 6.47）。
这些结果表明，GNB3 C825T SNP与精神分裂症患者的RLS相关。然而，要证实这种关联需要未来进行更大规模的研究，严格控制药物的影响。
