Graduate School of Nursing Science, St. Luke's International University, 10-1 Akashicho, Chuo-ku, Tokyo, 1040044, Japan.
Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chigusa-ku, Nagoya, 4648681, Japan.
BMC Cancer. 2018 Mar 27;18(1):350. doi: 10.1186/s12885-018-4293-x.
Previous studies have indicated that people with malignant pleural mesothelioma (MPM) have a poor quality of life (QOL); however, information about the QOL of people with MPM in Japan is anecdotal. The aims of this study were to investigate the QOL of survivors of MPM in Japan and to determine the factors that correlate with their QOL.
This was a cross sectional study. The included patients were those diagnosed with MPM in Japan. We created a self-administered questionnaire consisting of 64 questions. The questionnaires were sent to hospitals and patient advocacy groups, distributed to the patients, completed, and sent back to the researchers by postal mail. QOL was assessed with the European Organization for Research and Treatment of Cancer 16 questionnaire (QLQ) and the short version of the core domains of the Comprehensive Quality of Life Outcome questionnaire (CoQoLo).
In total, 133 questionnaires were collected. The QLQ assessments demonstrated that the survivors of MPM most frequently complained of fatigue, pain, sleep disturbances, and dyspnea. The symptom scales were acceptable, but the functional scales were significantly poorer for the patients with poor performance statuses (PSs). The short CoQoLo assessment was very unfavorable for 'Being free from physical pain.' Being a long-term survivor and a survivor with a poor PS were significantly correlated with poor global health status.
Survivors of MPM have impaired function, a variety of symptoms, and lower QOL. Survivors of MPM, even those in good physical condition, need broad support.
先前的研究表明，恶性胸膜间皮瘤（MPM）患者的生活质量（QOL）较差；然而，关于日本 MPM 患者 QOL 的信息只是传闻。本研究旨在调查日本 MPM 幸存者的 QOL，并确定与他们 QOL 相关的因素。
这是一项横断面研究。纳入的患者为在日本诊断为 MPM 的患者。我们创建了一份自我管理问卷，共包含 64 个问题。问卷发送至医院和患者权益组织，分发给患者，填写完毕后由患者通过邮寄方式寄回给研究人员。使用欧洲癌症研究与治疗组织 16 项问卷（QLQ）和综合生活质量结局问卷（CoQoLo）核心领域的简短版评估 QOL。
共收集到 133 份问卷。QLQ 评估显示，MPM 幸存者最常抱怨疲劳、疼痛、睡眠障碍和呼吸困难。症状量表可接受，但功能量表在表现状态较差的患者中明显较差。简短的 CoQoLo 评估对“无身体疼痛”非常不利。作为长期幸存者和表现状态差的幸存者与较差的总体健康状况显著相关。
MPM 幸存者的功能受损、症状多样，生活质量较低。即使身体状况良好的 MPM 幸存者也需要广泛的支持。
