Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, School of Physics and Electronics, Shandong Normal University, No.88, Wenhua East Road, Lixia District, Jinan, Shandong, 250014, China.
Shandong Medical Imaging and Radiotherapy Engineering Research Center, Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, 250014, People's Republic of China.
Radiat Oncol. 2018 Mar 27;13(1):52. doi: 10.1186/s13014-018-0996-z.
The purpose of this work is to benchmark RapidPlan against clinical plans for liver Intensity-modulated radiotherapy (IMRT) treatment of patients with special anatomical characteristics, and to investigate the prediction capability of the general model (Model-G) versus our specific model (Model-S).
A library consisting of 60 liver cancer patients with IMRT planning was used to set up two models (Model-S, Model-G), using the RapidPlan knowledge-based planning system. Model-S consisted of 30 patients with special anatomical characteristics where the distance from planning target volume (PTV) to the right kidney was less than three centimeters and Model-G was configurated using all 60 patients in this library. Knowledge-based IMRT plans were created for the evaluation group formed of 13 patients similar to those included in Model-S by Model-G, Model-S and manually (M), named RPG-plans, RPS-plans and M-plans, respectively. The differences in the dose-volume histograms (DVHs) were compared, not only between RP-plans and their respective M-plans, but also between RPG-plans and RPS-plans.
For all 13 patients, RapidPlan could automatically produce clinically acceptable plans. Comparing RP-plans to M-plans, RP-plans improved V of PTV and had greater dose sparing in the right kidney. For the normal liver, RPG-plans delivered similar doses, while RPS-plans delivered a higher dose than M-plans. With respect to RapidPlan models, RPS-plans had better conformity index (CI) values and delivered lower doses to the right kidney V and maximizing point doses to spinal cord, while delivering higher doses to the normal liver.
The study shows that RapidPlan can create high-quality plans, and our specific model can improve the CI of PTV, resulting in more sparing of OAR in IMRT for individual liver cancer patients.
本研究旨在以临床肝癌调强放疗计划为基准，比较 RapidPlan 与针对具有特殊解剖结构的肝癌患者的特定模型（Model-S）和通用模型（Model-G）的预测能力。
使用包含 60 例肝癌调强放疗计划的病例库，通过 RapidPlan 知识库计划系统，分别建立 Model-S（包含 30 例计划靶区（PTV）至右肾距离小于 3 厘米的患者）和 Model-G（包含 60 例患者）。采用 Model-G 为 13 例与 Model-S 相似的患者生成知识库调强计划（称为 RPG 计划），并与手动计划（M）和 Model-S 生成的计划（称为 RPS 计划和 M 计划）进行比较。比较了 RP 计划与各自的 M 计划之间，以及 RPG 计划与 RPS 计划之间的剂量体积直方图（DVH）差异。
对于所有 13 例患者，RapidPlan 均可自动生成可接受的计划。与 M 计划相比，RP 计划提高了 PTV 的 V 值，并使右肾的剂量降低。对于正常肝脏，RP 计划给予相似的剂量，而 RPS 计划给予的剂量高于 M 计划。关于 RapidPlan 模型，RPS 计划的适形指数（CI）值更好，右肾 V 和脊髓最大点剂量的剂量降低，而正常肝脏的剂量升高。
本研究表明 RapidPlan 可生成高质量的计划，并且我们的特定模型可以提高 PTV 的 CI，从而在个体化肝癌调强放疗中更好地保护 OAR。
