Tomásová H, Lisý V, Trojan S, Stastný F
Research Institute of Child Development, Charles University, Prague.
Physiol Bohemoslov. 1987;36(4):361-4.
Changes in the level of plasma lipids (cholesterol, fatty acids and lipoproteins) were followed in young rats exposed once or repeatedly to hypobaric hypoxia. A single exposure to hypoxia increased the level of LDL lipoproteins but did not influence the concentration of cholesterol and fatty acids in 18-day-old rats. Repeated exposure to hypobaric hypoxia caused a statistically significant increase in the concentration of cholesterol, fatty acids, chylomicra, low density beta-lipoproteins (LDL) and very-low-density beta-lipoproteins (VLDL) in 18-day-old rats, while the level of high-density alpha-lipoproteins (HDL) decreased. In animals that had been repeatedly exposed to hypoxia in their youth, a significant decrease of the LDL lipoprotein fraction was observed at the age of 108 days.
对单次或反复暴露于低压低氧环境的幼鼠血浆脂质（胆固醇、脂肪酸和脂蛋白）水平的变化进行了跟踪研究。单次暴露于低氧环境会增加18日龄大鼠的低密度脂蛋白（LDL）水平，但不影响胆固醇和脂肪酸的浓度。反复暴露于低压低氧环境会使18日龄大鼠的胆固醇、脂肪酸、乳糜微粒、低密度β-脂蛋白（LDL）和极低密度β-脂蛋白（VLDL）浓度出现统计学上的显著升高，而高密度α-脂蛋白（HDL）水平则降低。在幼年时反复暴露于低氧环境的动物中，108日龄时观察到LDL脂蛋白组分显著降低。
