School of Health & Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.
Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, Victoria, Australia.
Curr Med Chem. 2018;25(34):4402-4415. doi: 10.2174/0929867325666180326161730.
In acute myocardial infarction (AMI), the first line of treatment is to rapidly restore blood flow to the ischemic myocardium to limit infarct size. It is now well established that though clearly beneficial, the positive outcomes of this intervention are limited by injury in response to the reperfusion itself in addition to the prior ischemia. This process is described as reperfusion injury and is considered to contribute to the arrhythmias, microvascular dysfunction and impaired cardiac contractility that is observed even after the restoration of coronary blood flow. Thus an important, currently unmet, therapeutic challenge is to address the outcomes of this reperfusion injury. In this article, we review the evidence that flavonols and flavones may prove useful in preserving cardiac function after ischemia and reperfusion and consider the possible mechanisms, in particular, the inhibition of kinases, by which they may exert protection.
在急性心肌梗死（AMI）中，治疗的首要措施是迅速恢复缺血心肌的血流以限制梗死面积。目前已经明确，尽管这种干预措施显然是有益的，但除了先前的缺血之外，再灌注本身引起的损伤也限制了其积极效果。这一过程被描述为再灌注损伤，并且被认为导致了即使在冠状动脉血流恢复后仍观察到的心律失常、微血管功能障碍和心肌收缩功能受损。因此，一个重要的、目前尚未满足的治疗挑战是解决再灌注损伤的后果。在本文中，我们回顾了黄酮醇和黄酮类化合物在缺血和再灌注后可能有助于保护心脏功能的证据，并考虑了它们可能发挥保护作用的可能机制，特别是通过抑制激酶。
