Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
Science. 2018 Mar 9;359(6380):1143-1146. doi: 10.1126/science.aao4960.
Grid cells are neurons active in multiple fields arranged in a hexagonal lattice and are thought to represent the "universal metric for space." However, they become nonhomogeneously distorted in polarized enclosures, which challenges this view. We found that local changes to the configuration of the enclosure induce individual grid fields to shift in a manner inversely related to their distance from the reconfigured boundary. The grid remained primarily anchored to the unchanged stable walls and showed a nonuniform rescaling. Shifts in simultaneously recorded colocalized grid fields were strongly correlated, which suggests that the readout of the animal's position might still be intact. Similar field shifts were also observed in place and boundary cells-albeit of greater magnitude and more pronounced closer to the reconfigured boundary-which suggests that there is no simple one-to-one relationship between these three different cell types.
网格细胞是在多个排列成六边形晶格的区域中活跃的神经元，被认为代表了“空间的通用度量”。然而，它们在极化的容器中变得不均匀地变形，这对这种观点提出了挑战。我们发现，容器配置的局部变化会导致各个网格区域以与它们与重新配置边界的距离成反比的方式移动。网格主要仍然锚定在未改变的稳定壁上，并显示出非均匀的比例缩放。同时记录的局部化网格区域的移动具有很强的相关性，这表明动物位置的读出可能仍然完整。在位置和边界细胞中也观察到类似的场位移——尽管在重新配置的边界附近幅度更大且更为明显——这表明这三种不同类型的细胞之间没有简单的一一对应关系。
