Department of Animal and Poultry Science, University of Saskatchewan, 51 campus drive, Saskatoon, SK, S7N 5A8, Canada.
Phileo-Lesaffre Animal Care, Lesaffre group France, Paris, France.
Sci Rep. 2018 Mar 28;8(1):5315. doi: 10.1038/s41598-018-23373-8.
As an alternative to antibiotic growth promoters, live yeast supplementation has proven useful in reducing weaning stress and improving performance parameters of piglets. Here, we compared the performance and hindgut microbiota of weanling piglets subjected to different pre- and post-weaning yeast supplementation regimens using a live strain of Saccharomyces cerevisiae (Actisaf Sc 47). Average feed intake and average daily weight gain of piglets within Yeast-Control and Yeast-Yeast groups were higher than those in the Control-Control group. Yeast supplementation resulted in development of microbial communities that were phylogenetically more homogenous and less dispersed compared to the microbiota of control piglets. Key bacterial taxa overrepresented in the microbiota of yeast supplemented piglets included phylum Actinobacteria, specifically family Coriobacteriaceae, as well as Firmicutes families Ruminococcaceae, Clostridiaceae, Peptostreptococcaceae, and Peptococcaceae. Correlation network analysis revealed that yeast supplementation was associated with enrichment of positive correlations among proportions of different bacterial genera within the hindgut ecosystem. In particular, within the cecal microbiota of supplemented piglets, higher numbers of positive correlations were observed among potentially beneficial genera of the phyla Actinobacteria and Firmicutes, suggesting a mechanism by which yeast supplementation may contribute to regulation of intestinal homeostasis and improved performance of piglets.
作为抗生素生长促进剂的替代品，酵母补充剂已被证明可有效减少断奶应激，改善仔猪的性能参数。在这里，我们使用活的酿酒酵母（Actisaf Sc 47）比较了不同的预断奶和断奶后酵母补充方案对断奶仔猪的性能和后肠微生物群的影响。酵母控制组和酵母-酵母组仔猪的平均采食量和平均日增重均高于对照-对照组。与对照仔猪的微生物群相比，酵母补充导致微生物群落的进化更同质，分散性更低。在酵母补充仔猪的微生物群中过度表达的关键细菌分类群包括厚壁菌门，特别是科 Coriobacteriaceae，以及拟杆菌科、梭菌科、消化球菌科和消化链球菌科。相关网络分析表明，酵母补充与后肠生态系统中不同细菌属比例之间正相关的富集有关。特别是在补充仔猪的盲肠微生物群中，观察到潜在有益的厚壁菌门和拟杆菌门属之间的正相关数量增加，这表明酵母补充可能有助于调节肠道内稳态和改善仔猪性能的机制。
