Department of Pharmaceutics and Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Gujarat, India.
Int J Nanomedicine. 2018 Mar 15;13(T-NANO 2014 Abstracts):97-100. doi: 10.2147/IJN.S124692. eCollection 2018.
Mannosylated polymeric nanoparticles (NPs) enable improvement of brain bioavailability and reduction of dosing due to efficient drug delivery at the target site. Mannose receptors are present on the surface of macrophages, and therefore, in this study, it is expected that mannosylated NPs of anti-human immunodeficiency virus drug may target the macrophages, which may improve the therapeutic outcome and reduce the toxicity of antiretroviral bioactives. Poly(lactic-co-glycolic acid) (PLGA) and mannosylated-PLGA NPs (Mn-PLGA NPs) were prepared and administered by intravenous route in a dose of 10 mg/kg. After predetermined time period, the pharmacokinetics and biodistribution of NPs were analyzed using high-performance liquid chromatography and confocal microscopy, respectively. Results of this study indicated that Mn-PLGA NPs would be a promising therapeutic system for efficient delivery of the drug into brain macrophages.
甘露糖化聚合物纳米粒子（NPs）能够通过在靶部位有效递药来提高脑生物利用度并减少用药剂量。甘露糖受体存在于巨噬细胞的表面，因此，在这项研究中，预计抗人类免疫缺陷病毒药物的甘露糖化 NPs 可能靶向巨噬细胞，这可能改善治疗效果并降低抗逆转录病毒生物活性物质的毒性。聚（乳酸-共-乙醇酸）（PLGA）和甘露糖化-PLGA NPs（Mn-PLGA NPs）通过静脉途径以 10 mg/kg 的剂量给药。在预定的时间周期后，分别使用高效液相色谱法和共聚焦显微镜分析 NPs 的药代动力学和生物分布。本研究结果表明，Mn-PLGA NPs 将是一种有前途的治疗系统，可有效将药物递送至脑巨噬细胞。
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