McCance D R, Coulter D, Smye M, Kennedy L
Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Belfast, Northern Ireland.
Diabet Med. 1987 Sep-Oct;4(5):434-6. doi: 10.1111/j.1464-5491.1987.tb00904.x.
Serum fructosamine, albumin and plasma glucose were studied in eight patients during recovery from diabetic ketoacidosis, and in eight patients with "decompensated" diabetes without acidosis. In the ketoacidotic group, serum fructosamine had fallen significantly by a mean of 12% by 8h, and fell further during the remainder of the study. A smaller but significant fall in fructosamine (mean 6.1%) was seen in the decompensated group after only 18 h, with again a further fall thereafter. These changes in serum fructosamine were accompanied by decreases in serum albumin. However, when fructosamine was corrected by calculating a fructosamine/albumin index (FAI) (fructosamine X 100/albumin), the FAI did not change significantly in either group until a small reduction was noted in the ketoacidotic group at 5 days, which might reasonably be expected as an index of intermediate-term glycaemia. Therefore minor fluctuations in albumin levels seen in diabetic patients can affect fructosamine, and correction may be be advisable for the test to be a valid measure of glycosylated serum proteins.
对8例糖尿病酮症酸中毒恢复期患者和8例无酸中毒的“失代偿性”糖尿病患者的血清果糖胺、白蛋白和血糖进行了研究。在酮症酸中毒组中，血清果糖胺在8小时内显著下降，平均下降12%，在研究的其余时间进一步下降。在失代偿组中，仅18小时后果糖胺就出现了较小但显著的下降（平均6.1%），此后再次下降。血清果糖胺的这些变化伴随着血清白蛋白的降低。然而，当通过计算果糖胺/白蛋白指数（FAI）（果糖胺×100/白蛋白）来校正果糖胺时，两组的FAI直到第5天酮症酸中毒组出现小幅下降之前均无显著变化，这作为中期血糖指标是可以合理预期的。因此，糖尿病患者白蛋白水平的微小波动会影响果糖胺，为使该检测成为糖基化血清蛋白的有效测量方法，校正可能是可取的。
