Departamento de Química Analítica, Instituto Universitario de Investigación en Química Fina y Nanoquímica IUNAN, Universidad de Córdoba, Campus de Rabanales, Edificio Marie Curie, E-14071, Córdoba, Spain.
Department of Analytical Chemistry, University of Valencia, Dr. Moliner 50, 46100, Burjassot, Valencia, Spain.
Mikrochim Acta. 2018 Jan 24;185(2):127. doi: 10.1007/s00604-017-2659-4.
This work evaluates the potential of methacrylate monoliths with multi-walled carbon nanotubes incorporated into the polymeric network for the extraction of antidepressants from human urine. The method is based on a micropipette solid-phase extraction tip containing a hybrid monolithic material covalently attached to the polypropylene housing. A polymer layer made from poly(ethylene dimethacrylate) was bound to the inner surface of a polypropylene tip via UV grafting. The preparation of the monolith and the microextraction steps were optimized in terms of adsorption capacity. Limits of detection ranged from 9 to 15 μg·L. The average precision of the method varied between 3 and 5% (intra-tips), and from 4 to 14% (inter-tips). The accuracy of the method was evaluated through a recovery study by using spiked samples. Graphical abstract Hybrid polymer monoliths containing multi-walled carbon nanotubes (MWCNTs) were prepared in pipette tips by photo-polymerization approach. The extraction devices were used for the extraction of antidepressants in urine samples.
这项工作评估了将多壁碳纳米管纳入聚合物网络的甲基丙烯酸酯整体柱用于从人尿中提取抗抑郁药的潜力。该方法基于一种含有共价连接到聚丙烯外壳的混合整体材料的微量移液器固相萃取尖端。通过 UV 接枝将由聚（乙二醇二甲基丙烯酸酯）制成的聚合物层结合到聚丙烯尖端的内表面上。从吸附容量方面对整体柱的制备和微萃取步骤进行了优化。检测限范围为 9 至 15μg·L。该方法的平均精密度在 3%至 5%（内尖端）之间变化，在 4%至 14%（外尖端）之间变化。通过使用加标样品进行回收研究来评估该方法的准确性。
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