Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Court, Columbus, OH, 43210, USA.
Department of Microbiology, The Ohio State University, Columbus, OH, USA.
World J Microbiol Biotechnol. 2018 Mar 29;34(4):57. doi: 10.1007/s11274-018-2437-4.
Species that are currently listed under the genus Brevibacillus (formerly, Bacillus brevis cluster) have been a rich source of antimicrobial peptides for many decades. The first known peptide antibiotic, gramicidin, is presumed to be produced by a Brevibacillus sp. Members of the genus are widely spread in nature. They can be found in a variety of environments including intestinal tracts of animals, seawater, and soil. Some Brevibacillus strains have been used commercially as probiotics. Bioactive peptides produced by Brevibacillus spp. include antibacterial, antifungal and anti-invertebrate agents. Brevibacillus antimicrobial peptides are synthesized through ribosomal or nonribosomal pathway; these two groups can be further categorized based on specific structural features such as cyclization and presence of lipid chain. Some of the antimicrobial compounds produced by this genus share structural similarities that were overlooked previously. For example, the structural similarity between BT peptide, brevibacillin, and bogorol was revealed only recently. Here we review and classify Brevibacillus antimicrobial peptides and summarize their bioactivities and potential applications.
几十年来，目前被归为短芽孢杆菌属（以前称为短芽孢杆菌群）的物种一直是抗菌肽的丰富来源。第一个已知的肽抗生素，短杆菌肽，据推测是由短芽孢杆菌属产生的。该属的成员广泛分布在自然界中。它们可以在各种环境中找到，包括动物的肠道、海水和土壤。一些短芽孢杆菌菌株已被商业用作益生菌。短芽孢杆菌属产生的生物活性肽包括抗菌、抗真菌和抗无脊椎动物的制剂。短芽孢杆菌抗菌肽是通过核糖体或非核糖体途径合成的；这两组可以根据特定的结构特征进一步分类，如环化和脂质链的存在。该属产生的一些抗菌化合物具有以前被忽视的结构相似性。例如，BT 肽、短杆菌素和 bogorol 之间的结构相似性直到最近才被揭示。在这里，我们综述和分类短芽孢杆菌抗菌肽，并总结它们的生物活性和潜在应用。
