Mahmoud Y I, Taha A, Soliman S
a Zoology Department, Faculty of Science , Ain Shams University , Cairo , Egypt.
Biotech Histochem. 2018;93(4):293-300. doi: 10.1080/10520295.2018.1437471. Epub 2018 Mar 29.
We evaluated the sterilizing effect of 3-monochloropropane-1, 2-diol (3-MCPD) in male Egyptian fruit bats (Rousettus aegyptiacus). We used three groups. One was treated with 70 mg/kg 3-MCPD for 4 days. The second group was treated with 3-MCPD as a bait formulation (known concentration of 3-MCPD mixed with a known amount of food). The third group was untreated controls. We compared the weights of the reproductive organs, histology of the testes, occurrence of spermatogenesis, and the count, motility and abnormalities of epididymal sperm of treated males with those of the untreated control group. 3-MCPD caused significantly decreased weights of reproductive organs, several testicular histological alterations and spermatogenic arrest accompanied by significant decreases in sperm count and motility, and significantly increased number of abnormal sperm. 3-MCPD bait was readily accepted by the animals. 3-MCPD, even in low doses and after limited exposure, disrupted spermatogenesis in males of the Egyptian fruit bat. Our findings have potential value for public health and agricultural authorities, and for vertebrate pest managers. 3-MCPD may have application for control of this pest.
我们评估了3-氯-1,2-丙二醇（3-MCPD）对雄性埃及果蝠（埃及果蝠）的绝育效果。我们使用了三组。一组用70毫克/千克的3-MCPD处理4天。第二组用3-MCPD作为诱饵制剂（已知浓度的3-MCPD与已知量的食物混合）处理。第三组为未处理的对照组。我们比较了处理过的雄性动物与未处理对照组在生殖器官重量、睾丸组织学、精子发生情况以及附睾精子的数量、活力和异常情况等方面的差异。3-MCPD导致生殖器官重量显著下降，睾丸出现多种组织学改变以及精子发生停滞，同时伴有精子数量和活力显著下降，异常精子数量显著增加。3-MCPD诱饵很容易被动物接受。3-MCPD即使在低剂量和有限暴露后，也会破坏埃及果蝠雄性的精子发生。我们的研究结果对公共卫生和农业当局以及脊椎动物害虫管理者具有潜在价值。3-MCPD可能可用于控制这种害虫。
