Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Food Chem Toxicol. 2019 Feb;124:10-16. doi: 10.1016/j.fct.2018.11.023. Epub 2018 Nov 16.
3-MCPD, a contaminant frequently detected in foodstuffs, has been reported to damage human kidneys and testes. Previous studies can be used to evaluate the risk to humans of exposure to excessive 3-MCPD for a short period. However, the effects of withdrawal after 3-MCPD exposure have rarely been studied. Adult male SD rats were orally administered 0, 36 and 72 mg 3-MCPD/kg b.w./day for 4 weeks, followed by a 7-week recovery period. 3-MCPD significantly reduced RBC, HGB and HCT levels, indicating a phenotype of anemia, which returned to normal after the recovery period. 3-MCPD induced dysfunction in the liver and kidneys, which were characterized by hepatomegaly and elevated serum ALT, TBIL levels, and nephromegaly and elevated serum urea, UA contents. These effects were also restored to normal after the recovery period. Although the abnormal levels of testosterone and progesterone returned to normal, 3-MCPD-induced atrophy in testes, decreased sperm concentration and motility, and an increased rate of teratosperm still existed after the recovery period. 3-MCPD can induce restorable anemia and dysfunction in liver and kidney but irreversibly damage the reproductive system with normal sex hormone levels. This study may provide a novel perspective for characterizing the ongoing risk of exposure to 3-MCPD.
3-MCPD，一种在食品中经常检测到的污染物，据报道会损害人类的肾脏和睾丸。以前的研究可用于评估人类短期暴露于过量 3-MCPD 的风险。然而，很少有研究关注 3-MCPD 暴露后的戒断效应。成年雄性 SD 大鼠经口给予 0、36 和 72mg 3-MCPD/kg bw/天，连续 4 周，随后进行为期 7 周的恢复期。3-MCPD 显著降低了 RBC、HGB 和 HCT 水平，表明出现了贫血表型，在恢复期后恢复正常。3-MCPD 诱导了肝脏和肾脏的功能障碍，表现为肝肿大和血清 ALT、TBIL 水平升高，以及肾肿大和血清尿素、UA 含量升高。这些效应在恢复期后也恢复正常。虽然睾丸酮和孕酮的异常水平恢复正常，但 3-MCPD 诱导的睾丸萎缩、精子浓度和活力降低以及畸形精子率升高在恢复期后仍然存在。3-MCPD 可诱导可逆性贫血和肝肾功能障碍，但在正常性激素水平下，对生殖系统造成不可逆转的损害。本研究可能为评估 3-MCPD 暴露的持续风险提供新的视角。
