中华旋螺环酰胺A，一种从软珊瑚中华软珊瑚中分离得到的新型氮杂螺环缬草烷倍半萜类化合物

Sinulaspirolactam A, a novel aza-spirocyclic valerenane sesquiterpenoid from soft coral Sinularia sp.

作者信息

Lai Wei, Qin Sheng-Ying, Zou Ge, Liao Xiao-Jian, Chen Guo-Dong, Zhang Hua, Zhao Bing-Xin, Xu Shi-Hai

机构信息

a Department of Chemistry, College of Chemistry and Materials Science , Jinan University , Guangzhou 510632 , China.

b Clinical Experimental Center , First Affiliated Hospital of Jinan University , Guangzhou 510632 , China.

出版信息

J Asian Nat Prod Res. 2019 May;21(5):494-501. doi: 10.1080/10286020.2018.1450393. Epub 2018 Mar 29.

DOI:10.1080/10286020.2018.1450393

PMID:29595069

Abstract

A novel valerenane sesquiterpenoid sinulaspirolactam A (1), together with five known compounds, was isolated from the soft coral Sinularia sp. Their structures were determined by spectroscopic analyses. The absolute configuration of 1 was established by ECD calculation. Compound 1 was the first example of valerenane sesquiterpenoid bearing an aza-spiro[4.5] ring moiety, the plausible biogenetic pathway of which was proposed. Cytotoxic activities of these compounds were also evaluated.

摘要

从软珊瑚中华软珊瑚中分离出一种新型的缬草烷倍半萜类化合物辛那螺内酰胺A（1）以及五种已知化合物。通过光谱分析确定了它们的结构。通过电子圆二色性（ECD）计算确定了1的绝对构型。化合物1是带有氮杂螺[4.5]环部分的缬草烷倍半萜类化合物的首个实例，并提出了其可能的生源合成途径。还评估了这些化合物的细胞毒性活性。