（-）-羟基林德内酯，一种来自柳珊瑚Menella sp.（软珊瑚科）的新型倍半萜。

(-)-Hydroxylindestrenolide, a new sesquiterpenoid from a gorgonian coral Menella sp. (Plexauridae).

作者信息

Kao Shih-Yao, Chang Yu-Chia, Su Jui-Hsin, Lu Mei-Chin, Chen Yung-Husan, Sheu Jyh-Horng, Wen Zhi-Hong, Wang Wei-Hsien, Kuo Yueh-Hsiung, Hwang Tsong-Long, Sung Ping-Jyun

机构信息

Graduate Institute of Marine Biotechnology, National Dong Hwa University, Taiwan.

出版信息

Chem Pharm Bull (Tokyo). 2011;59(8):1048-50. doi: 10.1248/cpb.59.1048.

DOI:10.1248/cpb.59.1048

PMID:21804253

Abstract

(-)-Hydroxylindestrenolide (1), an enantiomer of the known sesquiterpenoid, (+)-hydroxylindestrenolide (2), was isolated from a gorgonian coral identified as Menella sp. The structure, including the relative stereochemistry of 1 was established by spectroscopic methods and by comparison the spectral and physical data with those of 2. Sesquiterpenoid 1 exhibited marginal cytotoxicity toward HL-60 and K562 leukemia tumor cells, and displayed a weak inhibitory effect on superoxide anion generation at a concentration of 10 µg/ml by human neutrophils.

摘要

(-)-羟基豆甾醇内酯(1)是已知倍半萜类化合物(+)-羟基豆甾醇内酯(2)的对映体，它是从一种鉴定为Menella属的柳珊瑚中分离得到的。通过光谱方法并将其光谱和物理数据与化合物2的数据进行比较，确定了化合物1的结构，包括其相对立体化学结构。倍半萜类化合物1对HL-60和K562白血病肿瘤细胞表现出微弱的细胞毒性，并且在浓度为10μg/ml时，对人中性粒细胞产生超氧阴离子具有微弱的抑制作用。