Adil Mohd, Khan Rosina, Rupasinghe H P Vasantha
Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, Nova Scotia, Canada.
College of Applied Medical Sciences, King Khalid University, Khamis Mushait, Saudi Arabia.
Curr Drug Metab. 2018;19(8):695-703. doi: 10.2174/1389200219666180329150551.
Streptococcus pyogenes, a major human pathogen, causes a wide variety of invasive systemic infections such as acute pharyngitis, skin and soft-tissue infections, especially necrotizing fasciitis.
This review focuses on the properties of pathogenicity of S. pyogenes and outlines ways to combat infection caused by these bacteria through alternative plant-based medicine.
This Gram positive bacterium has an ability to form mature biofilm and this sessile life style plays an important role in S. pyogenes pathogenicity. The virulence of these bacteria is further strengthened by its ability to communicate within the micro-colonies through quorum sensing. Most treatments are now aimed at either elimination of this bacterium or suppression of its virulence. The emergence of antibiotic resistance among S. pyogenes and treatment failure has become an added concern globally. One of its virulence properties, biofilm formation, has made it more resistant to antibiotic therapy. This has vitalized the necessity for searching alternative therapies for its treatment. The growing research in herbal medicines has led to the discovery of various phytochemicals to limit the virulence of S. pyogenes.
化脓性链球菌是一种主要的人类病原体，可引起多种侵袭性全身感染，如急性咽炎、皮肤和软组织感染，尤其是坏死性筋膜炎。
本综述聚焦于化脓性链球菌的致病特性，并概述通过替代性植物药对抗这些细菌引起的感染的方法。
这种革兰氏阳性菌具有形成成熟生物膜的能力，这种固着生活方式在化脓性链球菌的致病性中起重要作用。这些细菌通过群体感应在微菌落内进行交流的能力进一步增强了其毒力。目前大多数治疗方法旨在消灭这种细菌或抑制其毒力。化脓性链球菌中抗生素耐药性的出现和治疗失败已成为全球范围内另一个令人担忧的问题。其毒力特性之一，即生物膜形成，使其对抗生素治疗更具抗性。这激发了寻找替代疗法治疗该病的必要性。对草药的研究不断增加，已发现多种植物化学物质可限制化脓性链球菌的毒力。
