Shobha Balagangadharaswamy, Ashwini Bagepalli Shivaram, Ghazwani Mohammed, Hani Umme, Atwah Banan, Alhumaidi Maryam S, Basavaraju Sumanth, Chowdappa Srinivas, Ravikiran Tekupalli, Wahab Shadma, Ahmad Wasim, Lakshmeesha Thimappa Ramachandrappa, Ansari Mohammad Azam
Department of Microbiology and Biotechnology, Bangalore University, Jnana Bharathi Campus, Bengaluru 560056, India.
Department of Microbiology, Sri Siddhartha Medical College, Tumkur 572107, India.
J Fungi (Basel). 2023 Jan 18;9(2):133. doi: 10.3390/jof9020133.
Antimicrobial resistance is a major global health concern and one of the gravest challenges to humanity today. Antibiotic resistance has been acquired by certain bacterial strains. As a result, new antibacterial drugs are urgently required to combat resistant microorganisms. Species of are known to produce a wide range of enzymes and secondary metabolites that can be exploited for the synthesis of nanoparticles. In the present study, was isolated from rhizosphere soil and used for the biosynthesis of ZnO NPs. To examine the antibacterial activity of ZnO NPs against human pathogens, and were used. The obtained antibacterial results show that the biosynthesized ZnO NPs were efficient antibacterial agents against the pathogens and , with an inhibition zone of 3-9 mm. The ZnO NPs were also effective in the prevention of biofilm formation and adherence. The current work shows that the MIC dosages of ZnO NPs (25, 50, and 75 μg/mL) have effective antibacterial activity and antibiofilm action against . As a result, ZnO NPs can be used as a part of combination therapy for drug-resistant infections, where biofilm development is critical for disease progression.
抗菌耐药性是一个重大的全球健康问题，也是当今人类面临的最严峻挑战之一。某些细菌菌株已经获得了抗生素耐药性。因此，迫切需要新的抗菌药物来对抗耐药微生物。已知 物种会产生多种酶和次生代谢产物，可用于纳米颗粒的合成。在本研究中，从根际土壤中分离出 并用于生物合成ZnO纳米颗粒。为了检测ZnO纳米颗粒对人类病原体的抗菌活性，使用了 和 。获得的抗菌结果表明，生物合成的ZnO纳米颗粒是针对病原体 和 的有效抗菌剂，抑菌圈为3 - 9毫米。ZnO纳米颗粒在预防 生物膜形成和黏附方面也很有效。目前的工作表明，ZnO纳米颗粒的最低抑菌浓度剂量（25、50和75μg/mL）对 具有有效的抗菌活性和抗生物膜作用。因此，ZnO纳米颗粒可用作耐药 感染联合治疗的一部分，其中生物膜形成对疾病进展至关重要。
