金属硫蛋白的化学与生物化学

Chemistry and biochemistry of metallothionein.

作者信息

Kägi J H, Kojima Y

机构信息

Biochemisches Institut, Universität Zürich, Switzerland.

出版信息

Experientia Suppl. 1987;52:25-61. doi: 10.1007/978-3-0348-6784-9_3.

DOI:10.1007/978-3-0348-6784-9_3

PMID:2959513

Abstract

A wealth of chemical, spectroscopic and structural data attest to the uniqueness of the metallothioneins as a group of novel bioinorganic structures. Their earmarking feature is the arrangement of "soft" metal ions in complexes with cysteine side chains to form discrete metal-thiolate clusters. In this review an account is given of the chemical characteristics of the 52 metallothioneins whose primary structures are now known completely or in part. Also included is an up-to-date summary of the spectroscopic properties and of the spatial structure models derived from X-ray diffraction crystallographic analysis and from two-dimensional nuclear magnetic resonance spectroscopy.

摘要

大量的化学、光谱和结构数据证明了金属硫蛋白作为一类新型生物无机结构的独特性。它们的显著特征是“软”金属离子与半胱氨酸侧链形成配合物，从而形成离散的金属硫醇盐簇。在这篇综述中，介绍了52种金属硫蛋白的化学特性，其一级结构现已全部或部分已知。还包括光谱性质以及从X射线衍射晶体分析和二维核磁共振光谱得出的空间结构模型的最新总结。